Increased Sister Chromatid Exchange Frequency at Xq27 Site in Affected Fragile X Males

Overview

Journal Am J Med Genet

Specialty Genetics

Date 1987 Apr 1

PMID 3591833

Citations 9

Authors

S L Wenger

J C Hennessey

M W STEELE

Affiliations

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Abstract

Sister chromatid exchange (SCE) was evaluated in peripheral blood lymphocytes cultured from normal subjects, fragile X carrier females, and fragile X affected males and in general did not differ among all subjects whether cells were grown in thymidine-deficient or complete medium. However, at the Xq27 site, SCE was significantly increased for fragile X affected males, particularly in cells grown in thymidine-deficient medium.

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