Microdystrophin Therapy Rescues Impaired Na Currents in Cardiac Purkinje Fibers From Dystrophin-Deficient Mdx Mice

Overview

Journal Circ Arrhythm Electrophysiol

Specialty Cardiology & Vascular Diseases

Date 2022 Aug 2

PMID 35917466

Authors

Janine Ebner

Xiufang Pan

Yongping Yue

Spyridon Sideromenos

Jessica Marksteiner

Xaver Koenig

Karlheinz Hilber

Dongsheng Duan

Affiliations

Soon will be listed here.

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References

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Ebner J, Uhrin P, Szabo P, Kiss A, Podesser B, Todt H . Reduced Na current in Purkinje fibers explains cardiac conduction defects and arrhythmias in Duchenne muscular dystrophy. Am J Physiol Heart Circ Physiol. 2020; 318(6):H1436-H1440. DOI: 10.1152/ajpheart.00224.2020. View

Sikkel M, Francis D, Howard J, Gordon F, Rowlands C, Peters N . Hierarchical statistical techniques are necessary to draw reliable conclusions from analysis of isolated cardiomyocyte studies. Cardiovasc Res. 2017; 113(14):1743-1752. PMC: 5852514. DOI: 10.1093/cvr/cvx151. View

Duan D, Goemans N, Takeda S, Mercuri E, Aartsma-Rus A . Duchenne muscular dystrophy. Nat Rev Dis Primers. 2021; 7(1):13. PMC: 10557455. DOI: 10.1038/s41572-021-00248-3. View

Duan D . Systemic AAV Micro-dystrophin Gene Therapy for Duchenne Muscular Dystrophy. Mol Ther. 2018; 26(10):2337-2356. PMC: 6171037. DOI: 10.1016/j.ymthe.2018.07.011. View