The Old and the New About the Contractile Vacuole of Trypanosoma Cruzi

Overview

Journal J Eukaryot Microbiol

Publisher Wiley

Specialties Microbiology
Parasitology

Date 2022 Aug 2

PMID 35916682

Authors

Veronica Jimenez

Kildare Miranda

Ingrid Augusto

Affiliations

Soon will be listed here.

Abstract

Osmoregulation is a conserved cellular process required for the survival of all organisms. In protists, the need for robust compensatory mechanisms that can maintain cell volume and tonicity within physiological range is even more relevant, as their life cycles are often completed in different environments. Trypanosoma cruzi, the protozoan pathogen responsible for Chagas disease, is transmitted by an insect vector to multiple types of mammalian hosts. The contractile vacuole complex (CVC) is an organelle that senses and compensates osmotic changes in the parasites, ensuring their survival upon ionic and osmotic challenges. Recent work shows that the contractile vacuole is also a key component of the secretory and endocytic pathways, regulating the selective targeting of surface proteins during differentiation. Here we summarize our current knowledge of the mechanisms involved in the osmoregulatory processes that take place in the vacuole, and we explore the new and exciting functions of this organelle in cell trafficking and signaling.

Citing Articles

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