The Contemporary Management of Cancers of the Sinonasal Tract in Adults

Overview

Journal CA Cancer J Clin

Publisher Wiley

Specialty Oncology

Date 2022 Aug 2

PMID 35916666

Authors

Rajat Thawani

Myung Sun Kim

Asad Arastu

Zizhen Feng

Malinda T West

Nicholas F Taflin

Kyaw Zin Thein

Ryan Li

Mathew Geltzeiler

Nancy Lee

Clifton David Fuller

Jennifer R Grandis

Charalampos S Floudas

Michael C Heinrich

Ehab Hanna

Ravi A Chandra

Affiliations

Soon will be listed here.

Abstract

Sinonasal malignancies make up <5% of all head and neck neoplasms, with an incidence of 0.5-1.0 per 100,000. The outcome of these rare malignancies has been poor, whereas significant progress has been made in the management of other cancers. The objective of the current review was to describe the incidence, causes, presentation, diagnosis, treatment, and recent developments of malignancies of the sinonasal tract. The diagnoses covered in this review included sinonasal undifferentiated carcinoma, sinonasal adenocarcinoma, sinonasal squamous cell carcinoma, and esthesioneuroblastoma, which are exclusive to the sinonasal tract. In addition, the authors covered malignances that are likely to be encountered in the sinonasal tract-primary mucosal melanoma, NUT (nuclear protein of the testis) carcinoma, and extranodal natural killer cell/T-cell lymphoma. For the purpose of keeping this review as concise and focused as possible, sarcomas and malignancies that can be classified as salivary gland neoplasms were excluded.

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