The Interplay Between Cognition, Depression, Anxiety, and Sleep in Primary Sjogren's Syndrome Patients

Overview

Journal Sci Rep

Specialty Science

Date 2022 Aug 1

PMID 35915312

Authors

Radjiv Goulabchand

Elodie Castille

Sophie Navucet

Damien Etchecopar-Etchart

Aurelie Matos

Alexandre Maria

Laure Anne Gutierrez

Alain Le Quellec

Nicolas Menjot de Champfleur

Audrey Gabelle

Philippe Guilpain

Affiliations

Soon will be listed here.

Abstract

Primary Sjögren's syndrome (pSS) is an autoimmune disease with frequent neurological involvement. Memory complaints are common, but their precise patterns remain unclear. We wanted to characterize patterns of neurocognitive profiles in pSS patients with cognitive complaints. Only pSS patients with memory complaints were included, prospectively. Cognitive profiles were compiled through a comprehensive cognitive evaluation by neuropsychologists. Evaluations of anxiety, depression, fatigue, sleep disorders and quality of life were performed for testing their interactions with cognitive profiles. All 32 pSS patients showed at least borderline cognitive impairment, and 17 (53%) exhibited a pathological cognitive profile: a hippocampal profile (37%), a dysexecutive profile (22%), and an instrumental profile (16%) (possible overlap). Regarding the secondary objectives: 37% of patients were depressed, and 48% exhibited a mild-to-severe anxiety trait. Sleep disorders were frequent (excessive daytime sleepiness (55%), high risk for sleep apnea (45%), and insomnia (77%)). Cognitive impairments could not be explained alone by anxiety, depression or sleep disorders. Fatigue level was strongly associated with sleep disorders. Our study highlights that cognitive complaints in pSS patients are supported by measurable cognitive impairments, apart from frequently associated disorders such as depression, anxiety or sleep troubles. Sleep disorders should be screened.

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