Tuberculosis Infection in Children

Overview

Journal J Nurse Pract

Publisher Elsevier

Specialty Nursing

Date 2022 Aug 1

PMID 35912314

Authors

Rebekah J Stewart

Jonathan Wortham

Farah Parvez

Sapna Bamrah Morris

Hannah L Kirking

Lindsay Hatzenbuehler Cameron

Andrea T Cruz

Affiliations

Soon will be listed here.

Abstract

Globally, tuberculosis (TB) is the leading cause of infectious disease mortality; however, clinicians in the United States are increasingly unfamiliar with TB and the recommended tests and treatment for latent TB infection. Compared with adults, children who develop TB more often develop severe disease, and children < 2 years are particularly susceptible to developing TB disease after initial infection. Nurse practitioners who work in primary care are on the front lines of identifying children at high risk and obtaining testing and treatment. This article reviews the clinical course for identifying children at risk for TB and provides updated guidelines for testing and treatment.

References

van Toorn R, Schaaf H, Laubscher J, Elsland S, Donald P, Schoeman J . Short intensified treatment in children with drug-susceptible tuberculous meningitis. Pediatr Infect Dis J. 2013; 33(3):248-52. DOI: 10.1097/INF.0000000000000065. View

Miramontes R, Hill A, Woodruff R, Lambert L, Navin T, Castro K . Tuberculosis Infection in the United States: Prevalence Estimates from the National Health and Nutrition Examination Survey, 2011-2012. PLoS One. 2015; 10(11):e0140881. PMC: 4633161. DOI: 10.1371/journal.pone.0140881. View

Diallo T, Adjobimey M, Ruslami R, Trajman A, Sow O, Baah J . Safety and Side Effects of Rifampin versus Isoniazid in Children. N Engl J Med. 2018; 379(5):454-463. DOI: 10.1056/NEJMoa1714284. View

Grant L, Hammitt L, Murdoch D, OBrien K, Scott J . Procedures for collection of induced sputum specimens from children. Clin Infect Dis. 2012; 54 Suppl 2:S140-5. PMC: 3297553. DOI: 10.1093/cid/cir1069. View

Marais B, Gie R, Schaaf H, Hesseling A, Obihara C, Starke J . The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era. Int J Tuberc Lung Dis. 2004; 8(4):392-402. View

. Severe isoniazid-associated liver injuries among persons being treated for latent tuberculosis infection - United States, 2004-2008. MMWR Morb Mortal Wkly Rep. 2010; 59(8):224-9. View

Lewinsohn D, Leonard M, LoBue P, Cohn D, Daley C, Desmond E . Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children. Clin Infect Dis. 2017; 64(2):111-115. PMC: 5504475. DOI: 10.1093/cid/ciw778. View

Murphy M, Wilmore S, Satta G, Witney A, Atzeni A, Sturgeon K . Occupational Tuberculosis despite Minimal Nosocomial Contact in a Health Care Worker Undergoing Treatment with a Tumor Necrosis Factor Inhibitor. Ann Am Thorac Soc. 2016; 13(12):2275-2277. DOI: 10.1513/AnnalsATS.201608-582LE. View

Comstock G, Baum C, Snider Jr D . Isoniazid prophylaxis among Alaskan Eskimos: a final report of the bethel isoniazid studies. Am Rev Respir Dis. 1979; 119(5):827-30. DOI: 10.1164/arrd.1979.119.5.827. View

10.

Dodd P, Gardiner E, Coghlan R, Seddon J . Burden of childhood tuberculosis in 22 high-burden countries: a mathematical modelling study. Lancet Glob Health. 2014; 2(8):e453-9. DOI: 10.1016/S2214-109X(14)70245-1. View

11.

Golub J, Cronin W, Obasanjo O, Coggin W, Moore K, Pope D . Transmission of Mycobacterium tuberculosis through casual contact with an infectious case. Arch Intern Med. 2001; 161(18):2254-8. DOI: 10.1001/archinte.161.18.2254. View

12.

Villarino M, Scott N, Weis S, Weiner M, Conde M, Jones B . Treatment for preventing tuberculosis in children and adolescents: a randomized clinical trial of a 3-month, 12-dose regimen of a combination of rifapentine and isoniazid. JAMA Pediatr. 2015; 169(3):247-55. PMC: 6624831. DOI: 10.1001/jamapediatrics.2014.3158. View

13.

Ziakas P, Mylonakis E . 4 months of rifampin compared with 9 months of isoniazid for the management of latent tuberculosis infection: a meta-analysis and cost-effectiveness study that focuses on compliance and liver toxicity. Clin Infect Dis. 2009; 49(12):1883-9. DOI: 10.1086/647944. View

14.

. Guidelines for the investigation of contacts of persons with infectious tuberculosis. Recommendations from the National Tuberculosis Controllers Association and CDC. MMWR Recomm Rep. 2005; 54(RR-15):1-47. View

15.

Njie G, Morris S, Yelk Woodruff R, Moro R, Vernon A, Borisov A . Isoniazid-Rifapentine for Latent Tuberculosis Infection: A Systematic Review and Meta-analysis. Am J Prev Med. 2018; 55(2):244-252. PMC: 6097523. DOI: 10.1016/j.amepre.2018.04.030. View

16.

Hirsch-Moverman Y, Shrestha-Kuwahara R, Bethel J, Blumberg H, Venkatappa T, Horsburgh C . Latent tuberculous infection in the United States and Canada: who completes treatment and why?. Int J Tuberc Lung Dis. 2014; 19(1):31-8. PMC: 5296762. DOI: 10.5588/ijtld.14.0373. View

17.

Spyridis N, Spyridis P, Gelesme A, Sypsa V, Valianatou M, Metsou F . The effectiveness of a 9-month regimen of isoniazid alone versus 3- and 4-month regimens of isoniazid plus rifampin for treatment of latent tuberculosis infection in children: results of an 11-year randomized study. Clin Infect Dis. 2007; 45(6):715-22. DOI: 10.1086/520983. View

18.

Haddad M, Raz K, Lash T, Hill A, Kammerer J, Winston C . Simple Estimates for Local Prevalence of Latent Tuberculosis Infection, United States, 2011-2015. Emerg Infect Dis. 2018; 24(10):1930-1933. PMC: 6154166. DOI: 10.3201/eid2410.180716. View

19.

Bibbins-Domingo K, C Grossman D, Curry S, Bauman L, Davidson K, Epling Jr J . Screening for Latent Tuberculosis Infection in Adults: US Preventive Services Task Force Recommendation Statement. JAMA. 2016; 316(9):962-9. DOI: 10.1001/jama.2016.11046. View

20.

Machingaidze S, Wiysonge C, Gonzalez-Angulo Y, Hatherill M, Moyo S, Hanekom W . The utility of an interferon gamma release assay for diagnosis of latent tuberculosis infection and disease in children: a systematic review and meta-analysis. Pediatr Infect Dis J. 2011; 30(8):694-700. DOI: 10.1097/INF.0b013e318214b915. View