Case Report: Papillary Lesions at the Mouth Floor May Mimic Sialadenoma Papilliferum

Overview

Journal Pathol Oncol Res

Specialty Oncology

Date 2022 Aug 1

PMID 35911440

Authors

Dawool Han

Eunae Sandra Cho

Jiho Park

Dongwook Kim

Affiliations

Soon will be listed here.

Abstract

Salivary gland tumor Sialadenoma papilliferum (SialP) clinically resembles papillary epithelial lesions, such as squamous papilloma (SqP) or verrucous leukoplakia. Pathological sampling including an adequate depth of both the mucosa and submucosa layer is required for discrimination between the diseases. Though ductal proliferation in the submucosa is characteristic in SialP, papillary lesions arising at the mouth floor, specifically near the ductal orifice, are more problematic. Salivary gland ductal ectasia, along with the overlying papillary hyperplasia, may mimic the biphasic tumorous growth pattern of SialP, making discrimination extremely difficult. Further cellular dysplasia in the papillary mucosal lesion raises the possibility of malignant transformation in a known benign lesion, SialP. Herein, we present a case of SqP at the mouth floor which mimicked both clinical and pathological features of SialP and compared it with a definite case of SialP. Moreover, we discuss major differential points that clinicians and pathologists should consider during diagnosis of oral papillary lesions arising near the salivary glands.

References

Bobos M, Hytiroglou P, Karkavelas G, Papakonstantinou C, Papadimitriou C . Sialadenoma papilliferum of bronchus. Virchows Arch. 2003; 443(5):695-9. DOI: 10.1007/s00428-003-0879-y. View

Sawada K, Momose S, Kawano R, Kohda M, Irie T, Mishima K . Immunohistochemical staining patterns of p53 predict the mutational status of TP53 in oral epithelial dysplasia. Mod Pathol. 2021; 35(2):177-185. DOI: 10.1038/s41379-021-00893-9. View

Hamilton J, Osborne R, Smith L . Sialadenoma papilliferum involving the nasopharynx. Ear Nose Throat J. 2005; 84(8):474-5. View

Ponniah I . A rare case of sialadenoma papilliferum with epithelial dysplasia and carcinoma in situ. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 104(2):e27-9. DOI: 10.1016/j.tripleo.2006.06.053. View

Gomes A, Sobral A, Loducca S, de Araujo V . Sialadenoma papilliferum: immunohistochemical study. Int J Oral Maxillofac Surg. 2004; 33(6):621-4. DOI: 10.1016/j.ijom.2003.10.019. View

Fowler C, Damm D . Sialadenoma Papilliferum: Analysis of Seven New Cases and Review of the Literature. Head Neck Pathol. 2017; 12(2):193-201. PMC: 5953874. DOI: 10.1007/s12105-017-0852-8. View

Shimoda M, Kameyama K, Morinaga S, Tanaka Y, Hashiguchi K, Shimada M . Malignant transformation of sialadenoma papilliferum of the palate: a case report. Virchows Arch. 2004; 445(6):641-6. DOI: 10.1007/s00428-004-1091-4. View

Rennie J, MacDonald D, Critchlow H . Sialadenoma papilliferum. A case report and review of the literature. Int J Oral Surg. 1984; 13(5):452-4. DOI: 10.1016/s0300-9785(84)80074-5. View

Abrams A, Finck F . Sialadenoma papilliferum. A previously unreported salivary gland tumor. Cancer. 1969; 24(5):1057-63. DOI: 10.1002/1097-0142(196911)24:5<1057::aid-cncr2820240529>3.0.co;2-l. View

10.

Miyamoto S, Ogawa T, Chikazu D . Sialadenoma papilliferum in the buccal mucosa detected on F-fluorodeoxyglucose-positron emission tomography. Br J Oral Maxillofac Surg. 2017; 55(7):727-729. DOI: 10.1016/j.bjoms.2017.05.004. View

11.

Levinsohn J, Sugarman J, Bilguvar K, McNiff J, Choate K, The Yale Center For Mendelian Genomics . Somatic V600E BRAF Mutation in Linear and Sporadic Syringocystadenoma Papilliferum. J Invest Dermatol. 2015; 135(10):2536-2538. PMC: 4567902. DOI: 10.1038/jid.2015.180. View

12.

Kronenberg J, Horowitz A, LEVENTON G . Sialadenoma papilliferum of the parotid gland. J Laryngol Otol. 1989; 103(11):1089-90. DOI: 10.1017/s0022215100111089. View

13.

Ohtomo R, Mori T, Shibata S, Tsuta K, Maeshima A, Akazawa C . SOX10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: a clue to the histogenesis for tumor diagnosis. Mod Pathol. 2013; 26(8):1041-50. DOI: 10.1038/modpathol.2013.54. View

14.

Konstantinova A, Kyrpychova L, Nemcova J, Sedivcova M, Bisceglia M, Kutzner H . Syringocystadenoma Papilliferum of the Anogenital Area and Buttocks: A Report of 16 Cases, Including Human Papillomavirus Analysis and HRAS and BRAF V600 Mutation Studies. Am J Dermatopathol. 2018; 41(4):281-285. DOI: 10.1097/DAD.0000000000001285. View

15.

Hsieh L, Wang P, Chen I, Liao C, Wang H, Chen M . Characteristics of mutations in the p53 gene in oral squamous cell carcinoma associated with betel quid chewing and cigarette smoking in Taiwanese. Carcinogenesis. 2001; 22(9):1497-503. DOI: 10.1093/carcin/22.9.1497. View

16.

Nakaguro M, Urano M, Ogawa I, Hirai H, Yamamoto Y, Yamaguchi H . Histopathological evaluation of minor salivary gland papillary-cystic tumours: focus on genetic alterations in sialadenoma papilliferum and intraductal papillary mucinous neoplasm. Histopathology. 2019; 76(3):411-422. DOI: 10.1111/his.13990. View

17.

Carneiro T, Marinho S, Verli F, Mesquita A, Lima N, Miranda J . Oral squamous papilloma: clinical, histologic and immunohistochemical analyses. J Oral Sci. 2009; 51(3):367-72. DOI: 10.2334/josnusd.51.367. View

18.

Mahajan D, Khurana N, Setia N . Sialadenoma papilliferum in a young patient: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 103(3):e51-4. DOI: 10.1016/j.tripleo.2006.01.012. View

19.

Hsieh M, Bishop J, Wang Y, Poh C, Cheng Y, Lee Y . Salivary Sialadenoma Papilliferum Consists of Two Morphologically, Immunophenotypically, and Genetically Distinct Subtypes. Head Neck Pathol. 2019; 14(2):489-496. PMC: 7235136. DOI: 10.1007/s12105-019-01068-4. View

20.

Gomes C, Diniz M, Azevedo Orsine L, Duarte A, Fonseca-Silva T, Conn B . Assessment of TP53 mutations in benign and malignant salivary gland neoplasms. PLoS One. 2012; 7(7):e41261. PMC: 3400573. DOI: 10.1371/journal.pone.0041261. View