Heterocyclic Aromatic Amines and Risk of Kidney Stones: A Cross-Sectional Study in US Adults

Overview

Journal Front Public Health

Specialty Public Health

Date 2022 Aug 1

PMID 35910865

Authors

Guangyuan Zhang

Xiangyu Zou

Weipu Mao

Ming Chen

Affiliations

Soon will be listed here.

Abstract

Background: Heterocyclic aromatic amines (HAAs) are a group of harmful substances produced while cooking meat at high temperatures. This study aimed to investigate the relationship between HAAs and the occurrence of kidney stones.

Methods: Data on the level of four HAAs, including 2-Amino-9H-pyrido [2, 3-b] indole (A-α-C), 1-Methyl-9H-pyrido [3, 4-b] indole (Harman), 9H-Pyrido [3, 4-b] indole (Norharman), and 2-Amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP), in the urine from adult participants were extracted from the 2013-2014 NHANES database. Propensity score matching (PSM) was used to balance confounding variables between the stone former and non-stone former groups, and logistic regression analysis was performed to analyze the relationship between HAAs and the occurrence of kidney stones.

Results: Of the 1,558 eligible participants, a history of kidney stones was self-reported by 140 (9.0%). Compared to non-stone formers, stone formers had higher concentrations of A-α-C, Harman, and Norharman and lower concentrations of PhlP in urine. After adjusting for all other confounding variables, multivariate logistic regression analysis showed that the high-Harman group had a higher risk of kidney stones than the low-Harman group [adjusted odds ratios (aOR) = 1.618, 95% CI: 1.076-2.433, = 0.021]. After PSM analysis, Harman concentration remained a risk factor for kidney stones (high-Harman group vs. low-Harman group: aOR = 1.951, 95% CI: 1.059-3.596, = 0.032).

Conclusion: Increased urinary Harman concentrations are associated with an increased risk of kidney stones in the general US population.

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References

Zhang Y, Wu W, Zhou W, Ren Z, Feng X, Zhang F . Determination of 14 heterocyclic aromatic amines in meat products using solid-phase extraction and supercritical fluid chromatography coupled to triple quadrupole mass spectrometry. J Sep Sci. 2020; 43(7):1372-1381. DOI: 10.1002/jssc.201900816. View

Zeng G, Mai Z, Xia S, Wang Z, Zhang K, Wang L . Prevalence of kidney stones in China: an ultrasonography based cross-sectional study. BJU Int. 2017; 120(1):109-116. DOI: 10.1111/bju.13828. View

Nettuwakul C, Praditsap O, Sawasdee N, Rungroj N, Ruamyod K, Watanapa W . Loss-of-function mutations of SCN10A encoding Na1.8 α subunit of voltage-gated sodium channel in patients with human kidney stone disease. Sci Rep. 2018; 8(1):10453. PMC: 6041274. DOI: 10.1038/s41598-018-28623-3. View

Khan M, Azam M . Shrimp as a substantial source of carcinogenic heterocyclic amines. Food Res Int. 2021; 140:109977. DOI: 10.1016/j.foodres.2020.109977. View

Rohrmann S, Zoller D, Hermann S, Linseisen J . Intake of heterocyclic aromatic amines from meat in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heidelberg cohort. Br J Nutr. 2008; 98(6):1112-5. DOI: 10.1017/s000711450778145x. View

Turesky R, Garner R, Welti D, Richoz J, Leveson S, Dingley K . Metabolism of the food-borne mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in humans. Chem Res Toxicol. 1998; 11(3):217-25. DOI: 10.1021/tx9701891. View

Bylsma L, Alexander D . A review and meta-analysis of prospective studies of red and processed meat, meat cooking methods, heme iron, heterocyclic amines and prostate cancer. Nutr J. 2015; 14:125. PMC: 4687294. DOI: 10.1186/s12937-015-0111-3. View

Sun S, Mao W, Tao S, Zou X, Tian S, Qian S . Polycyclic Aromatic Hydrocarbons and the Risk of Kidney Stones in US Adults: An Exposure-Response Analysis of NHANES 2007-2012. Int J Gen Med. 2021; 14:2665-2676. PMC: 8232959. DOI: 10.2147/IJGM.S319779. View

Howles S, Thakker R . Genetics of kidney stone disease. Nat Rev Urol. 2020; 17(7):407-421. DOI: 10.1038/s41585-020-0332-x. View

10.

Syeda T, Cannon J . Potential Role of Heterocyclic Aromatic Amines in Neurodegeneration. Chem Res Toxicol. 2022; 35(1):59-72. PMC: 10443083. DOI: 10.1021/acs.chemrestox.1c00274. View

11.

Norsworthy A, Pearson M . From Catheter to Kidney Stone: The Uropathogenic Lifestyle of Proteus mirabilis. Trends Microbiol. 2016; 25(4):304-315. PMC: 5365347. DOI: 10.1016/j.tim.2016.11.015. View

12.

Wang Y, Peng L, Bellamri M, Langouet S, Turesky R . Mass Spectrometric Characterization of Human Serum Albumin Adducts Formed with N-Oxidized Metabolites of 2-Amino-1-methylphenylimidazo[4,5-b]pyridine in Human Plasma and Hepatocytes. Chem Res Toxicol. 2015; 28(5):1045-59. PMC: 4437839. DOI: 10.1021/acs.chemrestox.5b00075. View

13.

Guinez M, Canales R, Talio C, Gomez D, Smichowski P . Determination of heterocyclic aromatic amines in ashes from biomass burning by UHPLC-MS/MS after ultrasound-assisted dispersive solid-liquid microextraction. Talanta. 2019; 206:120182. DOI: 10.1016/j.talanta.2019.120182. View

14.

Wong K, Su J, Knize M, Koh W, Seow A . Dietary exposure to heterocyclic amines in a Chinese population. Nutr Cancer. 2005; 52(2):147-55. DOI: 10.1207/s15327914nc5202_5. View

15.

Mao W, Wu J, Zhang Z, Xu Z, Xu B, Chen M . Neutrophil-lymphocyte ratio acts as a novel diagnostic biomarker for kidney stone prevalence and number of stones passed. Transl Androl Urol. 2021; 10(1):77-86. PMC: 7844488. DOI: 10.21037/tau-20-890. View

16.

Malfatti M, Kulp K, Knize M, Davis C, Massengill J, Williams S . The identification of [2-(14)C]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine metabolites in humans. Carcinogenesis. 1999; 20(4):705-13. DOI: 10.1093/carcin/20.4.705. View

17.

Khan M . Influence of food condiments on the formation of carcinogenic heterocyclic amines in cooked chicken and determination by LC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015; 32(3):307-14. DOI: 10.1080/19440049.2015.1008057. View

18.

Alsohaimi I, Khan M, Ali H, Azam M . Emergence of mutagenic/carcinogenic heterocyclic amines in traditional Saudi chicken dishes prepared from local restaurants. Food Chem Toxicol. 2019; 132:110677. DOI: 10.1016/j.fct.2019.110677. View

19.

Mao W, Hu Q, Chen S, Chen Y, Luo M, Zhang Z . Polyfluoroalkyl chemicals and the risk of kidney stones in US adults: A population-based study. Ecotoxicol Environ Saf. 2020; 208:111497. DOI: 10.1016/j.ecoenv.2020.111497. View

20.

Dong H, Xian Y, Li H, Bai W, Zeng X . Potential carcinogenic heterocyclic aromatic amines (HAAs) in foodstuffs: Formation, extraction, analytical methods, and mitigation strategies. Compr Rev Food Sci Food Saf. 2020; 19(2):365-404. DOI: 10.1111/1541-4337.12527. View