Application of Gestational Blood Glucose Control During Perinatal Period in Parturients with Diabetes Mellitus: Meta-Analysis of Controlled Clinical Studies

Overview

Journal Front Surg

Specialty General Surgery

Date 2022 Aug 1

PMID 35910483

Authors

Tingting Wang

Wei Zhang

Affiliations

Soon will be listed here.

Abstract

Background: Gestational diabetes mellitus (GDM) is a common metabolic disorder. Hyperglycemia may cause gestational hypertension, increase the probability of infection, abnormal embryonic development, and increase the abortion rate. Oral hypoglycemic drugs may be another effective means of blood glucose control in addition to insulin injection. We included controlled clinical studies for meta-analysis to understand the effect of oral hypoglycemic drugs in gestational diabetes.

Methods: The databases were searched with the keywords "" & "": Embase (January, 2000-August, 2021), Pubmed (January, 2000-August, 2021), Web of Science (January, 2000-August, 2021), Ovid (January, 2000-August, 2021), and to obtain the randomized controlled trial (RCT) literatures related to the treatment of gestational diabetes with oral hypoglycemic drugs, after screening, the language toolkit was used for the analysis.

Results: A total of 10 articles with a total of 1,938 patients were included, 7 studies used as an hypoglycemic agent. Meta-analysis showed that oral had no significant difference in fasting blood glucose levels after the intervention compared with insulin injection [= -0.35, 95%CI(-0.70,1.40), = 0.66, = 0.51], with no significant difference in postprandial blood glucose levels after intervention [= -2.20, 95%CI(-5.94,1.55), = -1.15, = 0.25], and no statistical difference in glycosylated hemoglobin [= 0.10, 95%CI(-0.17,-0.04), = -0.94, = 0.31]. was more conducive to reducing maternal weight during pregnancy than insulin [= -1.55, 95%CI(-2.77,-0.34), = -2.5, = 0.0123], reduced the abortion rate compared with insulin [= 0.81, 95%CI(0.63,1.05), = -2.61, = 0.015], and reduced cesarean section rate [= 0.66, 95%CI(0.49,0.90), = -3.95, = 0.0001].

Discussion: The application of oral hypoglycemic drug in blood glucose control of gestational diabetes can play a hypoglycemic effect equivalent to insulin and can control the weight of pregnant women, reduce the rate of abortion and cesarean section, and improve pregnancy outcomes.

Citing Articles

Diabetes Mellitus and Gynecological and Inflammation Disorders Increased the Risk of Pregnancy Loss in a Population Study.

Cheng C, Su S, Chien W, Chen R, Chung C, Cheng C Life (Basel). 2024; 14(7).

PMID: 39063657 PMC: 11277821. DOI: 10.3390/life14070903.

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