Global Distribution of Animal Sporotrichosis: A Systematic Review of Sporothrix Sp. Identified Using Molecular Tools

Overview

Journal Curr Res Microb Sci

Specialty Microbiology

Date 2022 Aug 1

PMID 35909607

Authors

Debora Salgado Morgado

Rodolfo Castro

Marcelo Ribeiro-Alves

Danielly Correa-Moreira

Julio Castro-Alves

Sandro Antonio Pereira

Rodrigo Caldas Menezes

Manoel Marques Evangelista Oliveira

Affiliations

Soon will be listed here.

Abstract

Sporotrichosis is a subcutaneous mycosis caused by thermodimorphic fungi of the genus Sporothrix. The phenotypic and genotypic differences of the isolates within the genus Sporothrix have been associated with their geographic distribution, virulence capacity, or clinical manifestation of sporotrichosis. Therefore, it is crucial to identify the causative agent of sporotrichosis. However, there are few case reports and studies in animals compared to those in humans, despite the substantial increase in the number of cases of sporotrichosis by zoonotic transmission, especially in endemic areas. Considering the epidemiological importance, taxonomic evolution and worldwide distribution of these fungi in the last decade, there is interest in identifying the species of the genus Sporothrix in different regions of the world. This study aimed to analyze the geographic distribution of animal sporotrichosis in the world, caused by pathogenic species identified by use of molecular tools. This systematic review of articles from 2007 to 2021 analyzed the geographic distribution of species that cause sporotrichosis in cats, dogs and other animals. It demonstrated that the most identified species were S. brasiliensis, isolated from cats in Brazil and S. schenckii isolated from cats in Malaysia. We show the lack of studies in global areas and reinforce the need to use molecular tools to identify and monitor potential pathogens.

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References

Correa-Moreira D, De Luca P, Romeo O, Menezes R, Paes R, Oliveira R . Tregs in the immune response of BALB/c mice experimentally infected with species of the genus. Future Microbiol. 2020; 15:1217-1225. DOI: 10.2217/fmb-2020-0046. View

Rodrigues A, de Hoog S, De Camargo Z . Emergence of pathogenicity in the Sporothrix schenckii complex. Med Mycol. 2012; 51(4):405-12. DOI: 10.3109/13693786.2012.719648. View

Oliveira D, Lopes P, Spader T, Mahl C, Tronco-Alves G, Lara V . Antifungal susceptibilities of Sporothrix albicans, S. brasiliensis, and S. luriei of the S. schenckii complex identified in Brazil. J Clin Microbiol. 2011; 49(8):3047-9. PMC: 3147739. DOI: 10.1128/JCM.00255-11. View

Marimon R, Cano J, Gene J, Sutton D, Kawasaki M, Guarro J . Sporothrix brasiliensis, S. globosa, and S. mexicana, three new Sporothrix species of clinical interest. J Clin Microbiol. 2007; 45(10):3198-206. PMC: 2045377. DOI: 10.1128/JCM.00808-07. View

Hektoen L, Perkins C . REFRACTORY SUBCUTANEOUS ABSCESSES CAUSED BY SPOROTHRIX SCHENCKII. A NEW PATHOGENIC FUNGUS. J Exp Med. 2009; 5(1):77-89. PMC: 2117997. DOI: 10.1084/jem.5.1.77. View

Boechat J, Oliveira M, Almeida-Paes R, Gremiao I, de Sa Machado A, Oliveira R . Feline sporotrichosis: associations between clinical-epidemiological profiles and phenotypic-genotypic characteristics of the etiological agents in the Rio de Janeiro epizootic area. Mem Inst Oswaldo Cruz. 2018; 113(3):185-196. PMC: 5804311. DOI: 10.1590/0074-02760170407. View

Kano R, Okubo M, Siew H, Kamata H, Hasegawa A . Molecular typing of Sporothrix schenckii isolates from cats in Malaysia. Mycoses. 2015; 58(4):220-4. DOI: 10.1111/myc.12302. View

Chakrabarti A, Bonifaz A, Gutierrez-Galhardo M, Mochizuki T, Li S . Global epidemiology of sporotrichosis. Med Mycol. 2014; 53(1):3-14. DOI: 10.1093/mmy/myu062. View

Duangkaew L, Yurayart C, Limsivilai O, Chen C, Kasorndorkbua C . Cutaneous sporotrichosis in a stray cat from Thailand. Med Mycol Case Rep. 2019; 23:46-49. PMC: 6312868. DOI: 10.1016/j.mmcr.2018.12.003. View

10.

Seyedmousavi S, Guillot J, Tolooe A, Verweij P, de Hoog G . Neglected fungal zoonoses: hidden threats to man and animals. Clin Microbiol Infect. 2015; 21(5):416-25. DOI: 10.1016/j.cmi.2015.02.031. View

11.

Oliveira M, Almeida-Paes R, Muniz M, Gutierrez-Galhardo M, Zancope-Oliveira R . Phenotypic and molecular identification of Sporothrix isolates from an epidemic area of sporotrichosis in Brazil. Mycopathologia. 2011; 172(4):257-67. DOI: 10.1007/s11046-011-9437-3. View

12.

Gremiao I, Rocha E, Montenegro H, Carneiro A, Xavier M, de Farias M . Guideline for the management of feline sporotrichosis caused by Sporothrix brasiliensis and literature revision. Braz J Microbiol. 2020; 52(1):107-124. PMC: 7966609. DOI: 10.1007/s42770-020-00365-3. View

13.

Makri N, Paterson G, Gregge F, Urquhart C, Nuttall T . First case report of cutaneous sporotrichosis ( species) in a cat in the UK. JFMS Open Rep. 2020; 6(1):2055116920906001. PMC: 7025424. DOI: 10.1177/2055116920906001. View

14.

Montenegro H, Rodrigues A, Dias M, da Silva E, Bernardi F, De Camargo Z . Feline sporotrichosis due to Sporothrix brasiliensis: an emerging animal infection in São Paulo, Brazil. BMC Vet Res. 2014; 10:269. PMC: 4244058. DOI: 10.1186/s12917-014-0269-5. View

15.

New D, Beukers A, Kidd S, Merritt A, Weeks K, van Hal S . Identification of multiple species and subpopulations among Australian clinical Sporothrix isolates using whole genome sequencing. Med Mycol. 2018; 57(7):905-908. DOI: 10.1093/mmy/myy126. View

16.

Correa-Moreira D, Menezes R, Romeo O, Borba C, Oliveira M . Clinical and Anatomopathological Evaluation of BALB/c Murine Models Infected with Isolates of Seven Pathogenic Species. Pathogens. 2021; 10(12). PMC: 8705601. DOI: 10.3390/pathogens10121647. View

17.

D F Gremiao I, Menezes R, Schubach T, Figueiredo A, Cavalcanti M, A Pereira S . Feline sporotrichosis: epidemiological and clinical aspects. Med Mycol. 2014; 53(1):15-21. DOI: 10.1093/mmy/myu061. View

18.

Kano R, Tsui C, Hamelin R, Anzawa K, Mochizuki T, Nishimoto K . The MAT1-1:MAT1-2 ratio of Sporothrix globosa isolates in Japan. Mycopathologia. 2014; 179(1-2):81-6. DOI: 10.1007/s11046-014-9808-7. View

19.

Rodrigues A, Cruz Choappa R, Fernandes G, de Hoog G, De Camargo Z . Sporothrix chilensis sp. nov. (Ascomycota: Ophiostomatales), a soil-borne agent of human sporotrichosis with mild-pathogenic potential to mammals. Fungal Biol. 2016; 120(2):246-64. DOI: 10.1016/j.funbio.2015.05.006. View

20.

Rodrigues A, Teixeira M, de Hoog G, Schubach T, Pereira S, Fernandes G . Phylogenetic analysis reveals a high prevalence of Sporothrix brasiliensis in feline sporotrichosis outbreaks. PLoS Negl Trop Dis. 2013; 7(6):e2281. PMC: 3688539. DOI: 10.1371/journal.pntd.0002281. View