The Characteristics of Glucose Metabolism and Functional Connectivity in Posterior Default Network During Nondemented Aging: Relationship with Executive Function Performance

Overview

Journal Cereb Cortex

Publisher Oxford University Press

Specialty Neurology

Date 2022 Jul 31

PMID 35909217

Authors

Kai Xu

Na Niu

Xin Li

Yuan Chen

Dandan Wang

Junying Zhang

Yaojing Chen

He Li

Dongfeng Wei

Kewei Chen

Ruixue Cui

Zhanjun Zhang

Li Yao

Affiliations

Soon will be listed here.

Abstract

Background: Understanding the characteristics of intrinsic connectivity networks (ICNs) in terms of both glucose metabolism and functional connectivity (FC) is important for revealing cognitive aging and neurodegeneration, but the relationships between these two aspects during aging has not been well established in older adults.

Objective: This study is to assess the relationship between age-related glucose metabolism and FC in key ICNs, and their direct or indirect effects on cognitive deficits in older adults.

Methods: We estimated the individual-level standard uptake value ratio (SUVr) and FC of eleven ICNs in 59 cognitively unimpaired older adults, then analyzed the associations of SUVr and FC of each ICN and their relationships with cognitive performance.

Results: The results showed both the SUVr and FC in the posterior default mode network (pDMN) had a significant decline with age, and the association between them was also significant. Moreover, both decline of metabolism and FC in the pDMN were significantly correlated with executive function decline. Finally, mediation analysis revealed the glucose metabolism mediated the FC decline with age and FC mediated the executive function deficits.

Conclusions: Our findings indicated that covariance between glucose metabolism and FC in the pDMN is one of the main routes that contributes to age-related executive function decline.

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