Two Cases of Thymic Cancer in Patients with Lynch Syndrome

Overview

Journal Intern Med

Specialty General Medicine

Date 2022 Jul 31

PMID 35908972

Authors

Mototsugu Watanabe

Kohji Tanakaya

Shinichi Furukawa

Toshio Shiotani

Yumiko Sato

Fumitaka Taniguchi

Nobuhiko Kanaya

Hideki Aoki

Koukichi Sugano

Hideyuki Ishida

Kiwamu Akagi

Kazuhiko Kataoka

Affiliations

Soon will be listed here.

Abstract

We herein report two cases of thymic cancer with Lynch syndrome showing a high frequency of microsatellite instability and loss of mismatch repair protein expression without MLH1 promoter hyper-methylation. In Case 1, a 71-year-old man had a pathogenic germline variant in MLH1 and underwent tumor resection. No relapse has been reported thus far. In Case 2, a 43-year-old man underwent genetic testing that also showed a pathogenic germline variant in MLH1. Since these two cases had MLH variants, we suspect a possible association between thymic cancer with Lynch syndrome and germline pathogenic variants in MLH1.

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