Haemostatic Defect in Non-immune Patients with Falciparum Malaria: No Evidence of Diffuse Intravascular Coagulation

Overview

Journal Br Med J

Specialty General Medicine

Date 1978 Aug 19

PMID 359086

Citations 3

Authors

J Vreeken

Affiliations

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Abstract

Nine non-immune patients with imported falciparum malaria were examined for signs of diffuse intravascular coagulation (DIC). Although all had thrombocytopenia initially and some later had a decline in plasma fibrinogen concentrations, DIC was never detected, even in severely affected patients with coma and kidney damage. None of the patients were given heparin and all recovered without residual symptoms. Heparin administration should probably be considered only when clear-cut DIC, which possibly never occurs in falciparum malaria, has been demonstrated.

Citing Articles

A Systematic Review and Meta-Analysis of the Proportion Estimates of Disseminated Intravascular Coagulation (DIC) in Malaria.

Duangchan T, Kotepui M, Sukati S, Rattanapan Y, Wangdi K Trop Med Infect Dis. 2023; 8(6).

PMID: 37368707 PMC: 10301305. DOI: 10.3390/tropicalmed8060289.

Malaria-induced thrombocytopenia.

Horstmann R, Dietrich M, Bienzle U, Rasche H Blut. 1981; 42(3):157-64.

PMID: 7011445 DOI: 10.1007/BF01026385.

Haemostatic alterations in malaria correlate to parasitaemia.

Horstmann R, Dietrich M Blut. 1985; 51(5):329-35.

PMID: 3933596 DOI: 10.1007/BF00320043.

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