Keynote Address at the ASBrS 2022 Annual Meeting Low-Risk Breast Cancer: When Is Local Therapy Enough?

Overview

Journal Ann Surg Oncol

Publisher Springer

Specialty Oncology

Date 2022 Jul 30

PMID 35907998

Authors

V Suzanne Klimberg

Affiliations

Soon will be listed here.

Abstract

Surgery, radiation, and chemotherapy have all been used to de-escalate the treatment of breast cancer patients. Despite its impact on local recurrence, systemic endocrine therapy (ET) has yet to be de-escalated, even though it has substantial adverse effects and a lower quality of life (QoL) over 5-10 years. The 21-gene recurrence score (RS) and MammaPrint have been used to identify subgroups of younger patients whose long-term survival is unaffected by adjuvant ET. Local treatment only, with de-escalation of long-term systemic ET for patients aged 50-69 with RS < 11, appears not to impact OS and should have an anticipated improvement in QoL.

Citing Articles

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Fisher C, Teshome M, Blair S Ann Surg Oncol. 2022; 29(10):6087-6089.

PMID: 35902494 PMC: 9333076. DOI: 10.1245/s10434-022-12263-z.

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