» Articles » PMID: 35907969

Anti-müllerian Hormone As a Predictor for Live Birth Among Women Undergoing IVF/ICSI in Different Age Groups: an Update of Systematic Review and Meta-analysis

Overview
Date 2022 Jul 30
PMID 35907969
Authors
Affiliations
Soon will be listed here.
Abstract

Purpose: To update the evidence of anti-müllerian hormone (AMH) as predictive factors for live birth outcome in women undergoing assisted conception and discover the modulating effect of age.

Methods: PubMed, Embase, Medline, and Web of Science were searched for studies published until June 2021. We included studies that measured serum AMH levels and reported the subsequent live birth outcomes. Random effects models and hierarchical summary receiver operating characteristics (HSROC) models were used. The QUADAS-2 checklist was employed to assess the quality of the included studies.

Results: We included 27 studies (27,029 women) investigating the relationship between AMH and live birth outcome after assisted conception. The diagnostic odds ratios (DOR) from random effects models were ruled out due to high heterogeneity. Our findings suggested that AMH was associated with live birth. The DOR was 2.21 (95% CI 1.89-2.59), and 2.49 (95% CI 1.26-4.91) for studies on women with unspecified ovarian reserve and women with low ovarian reserve, respectively. The DOR of those with advanced ages was 2.50 (95% CI 1.87-2.60). For younger women, the DOR was 1.41 (95% CI 0.99-2.02). HSROCs showed that AMH had no predictive ability towards live birth in women with diminished ovarian reserve or younger age. Exclusion of Chinese cohorts lowered the heterogeneity.

Conclusions: This study revealed that AMH had better prediction for live birth in advanced-age women. AMH may have implicative predictive value for assisted conception counseling of couples of advanced ages.

Citing Articles

Derivation and validation of the first web-based nomogram to predict the spontaneous pregnancy after reproductive surgery using machine learning models.

Liu Z, Wang M, He S, Wang X, Liu X, Xie X Front Endocrinol (Lausanne). 2024; 15:1378157.

PMID: 39015183 PMC: 11250273. DOI: 10.3389/fendo.2024.1378157.


Anti-Müllerian hormone a surrogate of follicular fluid oxidative stress in polycystic ovary syndrome?.

Vale-Fernandes E, Moreira M, Rodrigues B, Pereira S, Leal C, Barreiro M Front Cell Dev Biol. 2024; 12:1408879.

PMID: 39011395 PMC: 11246868. DOI: 10.3389/fcell.2024.1408879.


The impact of ovarian endometrioma and endometriotic cystectomy on anti-Müllerian hormone, and antral follicle count: a contemporary critical appraisal of systematic reviews.

Younis J, Taylor H Front Endocrinol (Lausanne). 2024; 15:1397279.

PMID: 38800489 PMC: 11116636. DOI: 10.3389/fendo.2024.1397279.


Endometrial Elasticity is an Ultrasound Marker for Predicting Clinical Pregnancy Outcomes after Embryo Transfer.

Zhang L, Huang S, Wang L, Wang Y, Lu S, Li R Reprod Sci. 2024; 32(1):64-73.

PMID: 38769248 PMC: 11729198. DOI: 10.1007/s43032-024-01565-0.


Elevated Anti-Müllerian Hormone as a Prognostic Factor for Poor Outcomes of In Vitro Fertilization in Women with Polycystic Ovary Syndrome.

Vale-Fernandes E, Barreiro M, Leal C, Macedo R, Tome A, Monteiro M Biomedicines. 2023; 11(12).

PMID: 38137371 PMC: 10740605. DOI: 10.3390/biomedicines11123150.


References
1.
Seifer D, MacLaughlin D . Mullerian Inhibiting Substance is an ovarian growth factor of emerging clinical significance. Fertil Steril. 2007; 88(3):539-46. DOI: 10.1016/j.fertnstert.2007.02.014. View

2.
Muttukrishna S, Suharjono H, McGarrigle H, Sathanandan M . Inhibin B and anti-Mullerian hormone: markers of ovarian response in IVF/ICSI patients?. BJOG. 2004; 111(11):1248-53. DOI: 10.1111/j.1471-0528.2004.00452.x. View

3.
La Marca A, Sighinolfi G, Radi D, Argento C, Baraldi E, Artenisio A . Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART). Hum Reprod Update. 2009; 16(2):113-30. DOI: 10.1093/humupd/dmp036. View

4.
Muttukrishna S, McGarrigle H, Wakim R, Khadum I, Ranieri D, Serhal P . Antral follicle count, anti-mullerian hormone and inhibin B: predictors of ovarian response in assisted reproductive technology?. BJOG. 2005; 112(10):1384-90. DOI: 10.1111/j.1471-0528.2005.00670.x. View

5.
Rajpert-De Meyts E, Jorgensen N, Graem N, Muller J, Cate R, Skakkebaek N . Expression of anti-Müllerian hormone during normal and pathological gonadal development: association with differentiation of Sertoli and granulosa cells. J Clin Endocrinol Metab. 1999; 84(10):3836-44. DOI: 10.1210/jcem.84.10.6047. View