Oncogenic Roles of the LncRNA LINC00460 in Human Cancers

Overview

Journal Cancer Cell Int

Publisher Biomed Central

Date 2022 Jul 29

PMID 35906593

Authors

Min Su

Jinming Tang

Desong Yang

Zhining Wu

Qianjin Liao

Hui Wang

Yuhang Xiao

Wenxiang Wang

Affiliations

Soon will be listed here.

Abstract

Long noncoding RNAs (lncRNAs) represent an important group of endogenous RNAs with limit protein-encoding capability, with a length of more than 200 nucleotides. Emerging evidence have demonstrated that lncRNAs are greatly involved in multiple cancers by playing critical roles in tumor initiation and progression. Long intergenic non-protein coding RNA 460 (LINC00460), a novel cancer-related lncRNA, exhibits abnormal expression and oncogenic function in multiple cancers, and positively correlates with poor clinical characteristics of cancer patients. LINC00460 has also been shown to be a promising biomarker for diagnosis as well as prognostic evaluation in cancer patients. In this review, we briefly summarized recent knowledge on the expression, functional roles, molecular mechanisms, and diagnostic and prognostic values of LINC00460 in human malignancies.

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