Cholecalciferol Supplementation Effectively Improved Tertiary Hyperparathyroidism, FGF23 Resistance and Lowered Coronary Calcification Score: a Prospective Study

Overview

Journal Endocr Connect

Specialty Endocrinology

Date 2022 Jul 29

PMID 35904219

Authors

Shu-Meng Hu

Yang-Juan Bai

Ya-Mei Li

Ye Tao

Xian-Ding Wang

Tao Lin

Lan-Lan Wang

Yun-Ying Shi

Affiliations

Soon will be listed here.

Abstract

Introduction: Tertiary hyperparathyroidism (THPT) and vitamin D deficiency are commonly seen in kidney transplant recipients, which may result in persistently elevated fibroblast growth factor 23 (FGF23) level after transplantation and decreased graft survival. The aim of this study is to evaluate the effect of vitamin D supplementation on THPT, FGF23-alpha Klotho (KLA) axis and cardiovascular complications after transplantation.

Materials And Methods: Two hundred nine kidney transplant recipients were included and further divided into treated and untreated groups depending on whether they received vitamin D supplementation. We tracked the state of THPT, bone metabolism and FGF23-KLA axis within 12 months posttransplant and explored the predictors and risk factors for intact FGF23 levels, KLA levels, THPT and cardiovascular complications in recipients.

Results: Vitamin D supplementation significantly improved FGF23 resistance, THPT and high bone turnover status, preserved better graft function and prevented coronary calcification in the treated group compared to the untreated group at month 12. The absence of vitamin D supplementation was an independent risk factor for THPT and a predictor for intact FGF23 and KLA levels at month 12. Age and vitamin D deficiency were independent risk factors for coronary calcification in recipients at month 12.

Conclusion: Vitamin D supplementation effectively improved THPT, FGF23 resistance and bone metabolism, preserved graft function and prevented coronary calcification after transplantation.

Citing Articles

Vitamin D supplementation reduced blood inflammatory cytokines expression and improved graft function in kidney transplant recipients.

Bai Y, Li Y, Hu S, Zou Y, An Y, Wang L Front Immunol. 2023; 14:1152295.

PMID: 37483634 PMC: 10358325. DOI: 10.3389/fimmu.2023.1152295.

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