Thermo- and Light-Responsive Polymer-Coated Magnetic Nanoparticles As Potential Drug Carriers

Overview

Journal Front Bioeng Biotechnol

Date 2022 Jul 29

PMID 35903791

Authors

Guihua Cui

Hao Wang

Shengsen Long

Tianshuo Zhang

Xiaoyu Guo

Shuiying Chen

Toyoji Kakuchi

Qian Duan

Donghai Zhao

Affiliations

Soon will be listed here.

Abstract

A series of thermo- and light-responsive copolymers of poly (-isopropylacrylamide) (PNIPAM) and 6-[4-(4-methoxy phenyl azo)-phenoxyl-hexyl methacrylate) (AzoMA) (PNIPAM-b-PAzoMA) were synthesized reversible addition-fragmentation chain transfer (RAFT) radical polymerization. The resulting copolymers had a narrow molecular weight distribution range of 1.06-1.24, in which changed regularly with the monomer concentration. Subsequently, the diblock copolymers were successfully modified on the surface of iron oxide nanoparticles through the interaction between the chemical bonds to prepare FeO@(PNIPAM-b-PAzoMA) nanoparticles. The size of fabricated nanoparticles with excellent thermo-sensitivity and photo-sensitivity was controlled at about 40-50 nm. Cell viability assays suggested that the nanoparticles showed no significant cytotoxicity and potential drug delivery in the tumor microenvironment.

Citing Articles

Polymer-Based Drug Delivery Systems for Cancer Therapeutics.

Ding L, Agrawal P, Singh S, Chhonker Y, Sun J, Murry D Polymers (Basel). 2024; 16(6).

PMID: 38543448 PMC: 10974363. DOI: 10.3390/polym16060843.

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