Sedation Level with Midazolam: A Pediatric Surgery Approach

Overview

Journal Saudi Pharm J

Specialty Pharmacy

Date 2022 Jul 29

PMID 35903521

Authors

Carmen Flores-Perez

Luis Alfonso Moreno-Rocha

Juan Luis Chavez-Pacheco

Norma Angelica Noguez-Mendez

Janett Flores-Perez

Maria Fernanda Alcantara-Morales

Luz Cortes-Vasquez

Lina Sarmiento-Arguello

Affiliations

Soon will be listed here.

Abstract

Midazolam (MDZ) is a short-acting benzodiazepine that is widely used to induce and maintain general anesthesia during diagnostic and therapeutic procedures in pediatric patients due to its sedative properties. The aim of this study was to perform a systematic review without a meta-analysis to identify scientific articles and clinical assays concerning MDZ-induced sedation for a pediatric surgery approach. One hundred and twenty-eight results were obtained. After critical reading, 37 articles were eliminated, yielding 91 publications. Additional items were identified, and the final review was performed with a total of 106 publications. In conclusion, to use MDZ accurately, individual patient characteristics, the base disease state, comorbidities, the treatment burden and other drugs with possible pharmacological interactions or adverse reactions must be considered to avoid direct alterations in the pharmacokinetics and pharmacodynamics of MDZ to obtain the desired effects and avoid overdosing in the pediatric population.

Citing Articles

Pharmacokinetic-Pharmacodynamic Modeling of Midazolam in Pediatric Surgery.

Flores-Perez C, Moreno-Rocha L, Chavez-Pacheco J, Noguez-Mendez N, Flores-Perez J, Ortiz-Marmolejo D Pharmaceutics. 2023; 15(11).

PMID: 38004544 PMC: 10674765. DOI: 10.3390/pharmaceutics15112565.

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