Longitudinal Immune Response to 3 Doses of Messenger RNA Vaccine Against Coronavirus Disease 2019 (COVID-19) in Pediatric Patients Receiving Chemotherapy for Cancer

Overview

Journal Clin Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2022 Jul 28

PMID 35901198

Authors

Thomas Lehrnbecher

Ulrich Sack

Carsten Speckmann

Andreas H Groll

Andreas Boldt

Benjamin Siebald

Simone Hettmer

Eva-Maria Demmerath

Judith Reemtsma

Barbara Schenk

Sandra Ciesek

Jan-Henning Klusmann

Christian Jassoy

Sebastian Hoehl

Affiliations

Soon will be listed here.

Abstract

Our study in 21 pediatric cancer patients demonstrates that 3 doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA vaccine (BioNTech/Pfizer) elicited both humoral and cellular immunity in most patients during chemotherapy. Immunity was stronger in children with solid tumors and during maintenance therapy compared to those with hematological malignancies or during intensive chemotherapy. Clinical Trials Registration.ȃGerman Registry for Clinical Trials (DRKS00025254).

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