(Phospho)creatine: the Reserve and Merry-go-round of Brain Energetics

Overview

Journal Neural Regen Res

Date 2022 Jul 28

PMID 35900419

Authors

Hong-Ru Chen

Ton DeGrauw

Chia-Yi Kuan

Affiliations

Soon will be listed here.

Citing Articles

Detection of sex-specific glutamate changes in subregions of hippocampus in an early-stage Alzheimer's disease mouse model using GluCEST MRI.

Soni N, Swain A, Juul H, Cao Q, Haris M, Wolk D Alzheimers Dement. 2024; 20(10):7124-7137.

PMID: 39262197 PMC: 11485308. DOI: 10.1002/alz.14190.

References

Cecil K, Salomons G, Ball Jr W, Wong B, Chuck G, Verhoeven N . Irreversible brain creatine deficiency with elevated serum and urine creatine: a creatine transporter defect?. Ann Neurol. 2001; 49(3):401-4. DOI: 10.1002/ana.79. View

Monge C, Beraud N, Kuznetsov A, Rostovtseva T, Sackett D, Schlattner U . Regulation of respiration in brain mitochondria and synaptosomes: restrictions of ADP diffusion in situ, roles of tubulin, and mitochondrial creatine kinase. Mol Cell Biochem. 2008; 318(1-2):147-65. DOI: 10.1007/s11010-008-9865-7. View

Salford L, Siesjo B . The influence of arterial hypoxia and unilateral carotid artery occlusion upon regional blood flow and metabolism in the rat brain. Acta Physiol Scand. 1974; 92(1):130-41. DOI: 10.1111/j.1748-1716.1974.tb05729.x. View

Longo N, Ardon O, Vanzo R, Schwartz E, Pasquali M . Disorders of creatine transport and metabolism. Am J Med Genet C Semin Med Genet. 2011; 157C(1):72-8. DOI: 10.1002/ajmg.c.30292. View

Chen H, Zhang-Brotzge X, Morozov Y, Li Y, Wang S, Zhang H . Creatine transporter deficiency impairs stress adaptation and brain energetics homeostasis. JCI Insight. 2021; 6(17). PMC: 8492331. DOI: 10.1172/jci.insight.140173. View

Kan H, Meeuwissen E, van Asten J, Veltien A, Isbrandt D, Heerschap A . Creatine uptake in brain and skeletal muscle of mice lacking guanidinoacetate methyltransferase assessed by magnetic resonance spectroscopy. J Appl Physiol (1985). 2007; 102(6):2121-7. DOI: 10.1152/japplphysiol.01327.2006. View

Singh R, Cuervo A . Autophagy in the cellular energetic balance. Cell Metab. 2011; 13(5):495-504. PMC: 3099265. DOI: 10.1016/j.cmet.2011.04.004. View

Saks V, Kongas O, Vendelin M, Kay L . Role of the creatine/phosphocreatine system in the regulation of mitochondrial respiration. Acta Physiol Scand. 2000; 168(4):635-41. DOI: 10.1046/j.1365-201x.2000.00715.x. View

Wallimann T, Tokarska-Schlattner M, Schlattner U . The creatine kinase system and pleiotropic effects of creatine. Amino Acids. 2011; 40(5):1271-96. PMC: 3080659. DOI: 10.1007/s00726-011-0877-3. View

10.

Wyss M, Kaddurah-Daouk R . Creatine and creatinine metabolism. Physiol Rev. 2000; 80(3):1107-213. DOI: 10.1152/physrev.2000.80.3.1107. View

11.

Kim J, Kundu M, Viollet B, Guan K . AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 2011; 13(2):132-41. PMC: 3987946. DOI: 10.1038/ncb2152. View

12.

Kieburtz K, Tilley B, Elm J, Babcock D, Hauser R, Ross G . Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial. JAMA. 2015; 313(6):584-93. PMC: 4349346. DOI: 10.1001/jama.2015.120. View