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CAR T-cell Therapy Meets Clonal Hematopoiesis

Overview
Specialties Hematology
Oncology
Date 2022 Jul 27
PMID 35896010
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Abstract

Clonal hematopoiesis of indeterminate potential (CHIP) is common in patients with hematologic malignancies. Recent publications provide evidence that CHIP may affect chimeric antigen receptor T-cell therapy efficacy and that the incidence of treatment-related toxicities such as cytokine release syndrome and immune effector-cell associated neurotoxicity syndrome may be affected. See related article by Saini et al., p. 385 (8).

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