Phenolic Profile and Antioxidant, Anticholinergic, and Antibacterial Properties of Corn Tassel

Overview

Journal Plants (Basel)

Date 2022 Jul 27

PMID 35893603

Authors

Jameel M Al-Khayri

Arzu Kavaz Yuksel

Mehmet Yuksel

Mesut Isik

Emrah Dikici

Affiliations

Soon will be listed here.

Abstract

Corn tassel (CT) is a waste part of the corn plant. It is a good co-product and rich in terms of bioactive compounds and phytochemicals. This research tried to show the phenolic profile, antioxidants, anticholinergic activities, and antibacterial properties of CT ethanol extract. The phenolic content analysis of the CT was determined quantitatively by LC-MS/MS, and the antioxidant capacity was measured using ABTS, DPPH, Cu-Cu, and Fe-Fe reducing methods. The anticholinergic measurements of CT were detected by inhibition of acetylcholinesterase (AChE). The antibacterial activity was determined by MIC and disc diffusion methods. Many phenolic compounds such as vanillic acid, caffeic acid, fumaric acid, acetohydroxamic acid, butein, myricetin, resveratrol, catechin hydrate, and 4-hydroxybenzoic acid were detected in ethanol extract of CT. The obtained plant ethanol extract had a 7.04% DPPH value, while it showed ABTS activity at 9.45%. Moreover, it had a 0.10 mg/mL inhibition effect on the AChE in terms of IC values. The ethanol extract of the CT had an antibacterial property on the investigated bacteria at different ratios. In conclusion, this research aims to consider CT as a source of phenolic compounds and to reveal its bioactive properties and its effects on the treatment of some diseases.

Citing Articles

Therapeutic potential of extract by experimental and computational approaches: phenolic content and bioactivities for antioxidant, antidiabetic, and anticholinergic properties.

Altin S, Isik M, Alp C, Dikici E, Koksal E, Kirboga K Front Chem. 2025; 13:1541250.

PMID: 40046016 PMC: 11880275. DOI: 10.3389/fchem.2025.1541250.

Antioxidant, Enzyme-Inhibitory and Antimicrobial Activity of Underutilized Wheat and Maize Crop Residues.

Samardzic S, Velickovic I, Milenkovic M, Arsenijevic J, Medarevic D, Maksimovic Z Plants (Basel). 2025; 14(3).

PMID: 39942908 PMC: 11820700. DOI: 10.3390/plants14030346.

Optimization of Polyphenol Extraction from Purple Corn Pericarp Using Glycerol/Lactic Acid-Based Deep Eutectic Solvent in Combination with Ultrasound-Assisted Extraction.

Kumar R, Flint-Garcia S, Salazar Vidal M, Channaiah L, Vardhanabhuti B, Sommer S Antioxidants (Basel). 2025; 14(1).

PMID: 39857343 PMC: 11762350. DOI: 10.3390/antiox14010009.

Antimicrobial Impact of Wood Vinegar Produced Through Co-Pyrolysis of Eucalyptus Wood and Aromatic Herbs.

Gama G, Pimenta A, Feijo F, Martins Aires C, de Melo R, Dos Santos C Antibiotics (Basel). 2024; 13(11).

PMID: 39596750 PMC: 11590886. DOI: 10.3390/antibiotics13111056.

Antioxidant, antidiabetic effects and polyphenolic contents of propolis from Siirt, Turkey.

Oren E, Tuncay S, Toprak Y, Firat M, Toptanci I, Karasakal O Food Sci Nutr. 2024; 12(4):2772-2782.

PMID: 38628175 PMC: 11016413. DOI: 10.1002/fsn3.3958.

References

Zhu Z, Li J, Gao X, Amponsem E, Kang L, Hu L . Simultaneous determination of stilbenes, phenolic acids, flavonoids and anthraquinones in Radix polygoni multiflori by LC-MS/MS. J Pharm Biomed Anal. 2012; 62:162-6. DOI: 10.1016/j.jpba.2011.11.002. View

Zapata A, Ramirez-Arcos S . A comparative study of McFarland turbidity standards and the Densimat photometer to determine bacterial cell density. Curr Microbiol. 2015; 70(6):907-9. DOI: 10.1007/s00284-015-0801-2. View

Liu S, Willett W, Manson J, Hu F, Rosner B, Colditz G . Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women. Am J Clin Nutr. 2003; 78(5):920-7. DOI: 10.1093/ajcn/78.5.920. View

MIDDLETON Jr E . Effect of plant flavonoids on immune and inflammatory cell function. Adv Exp Med Biol. 1998; 439:175-82. DOI: 10.1007/978-1-4615-5335-9_13. View

Anwar J, Spanevello R, Thome G, Stefanello N, Schmatz R, Gutierres J . Effects of caffeic acid on behavioral parameters and on the activity of acetylcholinesterase in different tissues from adult rats. Pharmacol Biochem Behav. 2012; 103(2):386-94. DOI: 10.1016/j.pbb.2012.09.006. View

Koksal E, Tohma H, Kilic O, Alan Y, Aras A, Gulcin I . Assessment of Antimicrobial and Antioxidant Activities of Nepeta trachonitica: Analysis of Its Phenolic Compounds Using HPLC-MS/MS. Sci Pharm. 2017; 85(2). PMC: 5489928. DOI: 10.3390/scipharm85020024. View

Maksimovic Z, Dobric S, Kovacevic N, Milovanovic Z . Diuretic activity of Maydis stigma extract in rats. Pharmazie. 2005; 59(12):967-71. View

Isik M, Beydemir S . The impact of some phenolic compounds on serum acetylcholinesterase: kinetic analysis of an enzyme/inhibitor interaction and molecular docking study. J Biomol Struct Dyn. 2020; 39(17):6515-6523. DOI: 10.1080/07391102.2020.1801509. View

Isik M, Beydemir S, Yilmaz A, Naldan M, Aslan H, Gulcin I . Oxidative stress and mRNA expression of acetylcholinesterase in the leukocytes of ischemic patients. Biomed Pharmacother. 2017; 87:561-567. DOI: 10.1016/j.biopha.2017.01.003. View

10.

Demir Y, Isik M, Gulcin I, Beydemir S . Phenolic compounds inhibit the aldose reductase enzyme from the sheep kidney. J Biochem Mol Toxicol. 2017; 31(9). DOI: 10.1002/jbt.21935. View

11.

Melanson K, Angelopoulos T, Nguyen V, Martini M, Zukley L, Lowndes J . Consumption of whole-grain cereals during weight loss: effects on dietary quality, dietary fiber, magnesium, vitamin B-6, and obesity. J Am Diet Assoc. 2006; 106(9):1380-8. DOI: 10.1016/j.jada.2006.06.003. View

12.

WATTENBERG L . Inhibition of carcinogenesis by minor dietary constituents. Cancer Res. 1992; 52(7 Suppl):2085s-2091s. View

13.

Mukherjee P, Kumar V, Mal M, Houghton P . Acetylcholinesterase inhibitors from plants. Phytomedicine. 2007; 14(4):289-300. DOI: 10.1016/j.phymed.2007.02.002. View

14.

Stefani E, Boffetta P, Deneo-Pellegrini H, Mendilaharsu M, Carzoglio J, Ronco A . Dietary antioxidants and lung cancer risk: a case-control study in Uruguay. Nutr Cancer. 1999; 34(1):100-10. DOI: 10.1207/S15327914NC340114. View

15.

Tahraoui A, El-Hilaly J, Israili Z, Lyoussi B . Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south-eastern Morocco (Errachidia province). J Ethnopharmacol. 2006; 110(1):105-17. DOI: 10.1016/j.jep.2006.09.011. View

16.

Kim K, Choi S, Choi H . Corn silk induces nitric oxide synthase in murine macrophages. Exp Mol Med. 2005; 36(6):545-50. DOI: 10.1038/emm.2004.69. View

17.

Li C, Kim H, Won S, Min H, Park K, Park J . Corn husk as a potential source of anthocyanins. J Agric Food Chem. 2008; 56(23):11413-6. DOI: 10.1021/jf802201c. View

18.

Hanasaki Y, Ogawa S, Fukui S . The correlation between active oxygens scavenging and antioxidative effects of flavonoids. Free Radic Biol Med. 1994; 16(6):845-50. DOI: 10.1016/0891-5849(94)90202-x. View

19.

Anderson J, Hanna T, Peng X, Kryscio R . Whole grain foods and heart disease risk. J Am Coll Nutr. 2000; 19(3 Suppl):291S-299S. DOI: 10.1080/07315724.2000.10718963. View

20.

Mellen P, Walsh T, Herrington D . Whole grain intake and cardiovascular disease: a meta-analysis. Nutr Metab Cardiovasc Dis. 2007; 18(4):283-90. DOI: 10.1016/j.numecd.2006.12.008. View