Modification of Collagen Film Via Surface Grafting of Taurine Molecular to Promote Corneal Nerve Repair and Epithelization Process

Overview

Journal J Funct Biomater

Specialty Biomedical Engineering

Date 2022 Jul 27

PMID 35893466

Authors

Yang Liu

Chuanlei Zhang

Yanhui Kong

Huiyu Liu

Jia Guo

Hui Yang

Linhong Deng

Affiliations

Soon will be listed here.

Abstract

Corneal defects can seriously affect human vision, and keratoplasty is the most widely accepted therapy method for visual rehabilitation. Currently, effective treatment for clinical patients has been restricted due to a serious shortage of donated cornea tissue and high-quality artificial repair materials. As the predominant component of cornea tissue, collagen-based materials have promising applications for corneal repair. However, the corneal nerve repair and epithelization process after corneal transplantation must be improved. This research proposes a new collagen-based scaffold with good biocompatibility and biological functionality enhanced by surface chemical grafting of natural taurine molecular. The chemical composition of collagen-taurine (Col-Tau) material is evaluated by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, and its hydrophilic properties, light transmittance, swelling performance and mechanical tensile properties have been measured. The research results indicate that the Col-Tau sample has high transmittance and good mechanical properties, and exhibits excellent capacity to promote corneal nerve cell growth and the epithelization process of corneal epithelial cells. This novel Col-Tau material, which can be easily prepared at a low cost, should have significant application potential for the treating corneal disease in the future.

Citing Articles

Preparation and Characterization of a Photo-Crosslinked Methacryloyl-Collagen Composite Film to Promote Corneal Nerve Regeneration via Surface Grafting of Taurine Molecules.

Liu Y, Zhang C, Kong Y, Liu H, Chen C, Gao W Int J Mol Sci. 2023; 24(14).

PMID: 37511012 PMC: 10379273. DOI: 10.3390/ijms241411248.

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