Association of , and Polymorphisms in Patients with Colorectal Cancer and Type II Diabetes Mellitus

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2022 Jul 27

PMID 35893034

Authors

Anca Florentina Mitroi

Nicoleta Leopa

Eugen Dumitru

Costel Brinzan

Cristina Tocia

Andrei Dumitru

Razvan Catalin Popescu

Affiliations

Soon will be listed here.

Abstract

Background: The aim of the study is to explore the association between the rs7903146, rs6983267 and rs16969681 polymorphisms in patients diagnosed with type 2 diabetes mellitus (T2DM) and colorectal cancer.

Methods: Sixty individuals were enrolled in this case-control study: thirty with colorectal cancer and type II diabetes mellitus (T2DM) and thirty healthy control individuals. Real-time PCR was used to determine the genotypes of rs7903146, rs 6983267 and rs16969681 in patients with CRC and T2DM and in patients without T2DM and CRC. The Hardy-Weinberg equilibrium was determined in the control group for the genotype distribution of every polymorphism.

Results: People carrying the TT genotype of rs7903146, rs6983267 and rs1696981 had a significant association with T2DM and CRC. Moreover, the people with the TT genotype of rs1696981 had a greater risk for T2DM and CRC (OR = 7, CI 0.397-23.347).

Conclusions: rs7903146, rs6983267 and rs16969681 could be risk factors for the association of T2DM with CRC.

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