Dysregulation of Liver Regeneration by Hepatitis B Virus Infection: Impact on Development of Hepatocellular Carcinoma

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2022 Jul 27

PMID 35892823

Authors

Eun-Sook Park

Mehrangiz Dezhbord

Ah Ram Lee

Bo Bae Park

Kyun-Hwan Kim

Affiliations

Soon will be listed here.

Abstract

The liver is unique in its ability to regenerate in response to damage. The complex process of liver regeneration consists of multiple interactive pathways. About 2 billion people worldwide have been infected with hepatitis B virus (HBV), and HBV causes 686,000 deaths each year due to its complications. Long-term infection with HBV, which causes chronic inflammation, leads to serious liver-related diseases, including cirrhosis and hepatocellular carcinoma. HBV infection has been reported to interfere with the critical mechanisms required for liver regeneration. In this review, the studies on liver tissue characteristics and liver regeneration mechanisms are summarized. Moreover, the inhibitory mechanisms of HBV infection in liver regeneration are investigated. Finally, the association between interrupted liver regeneration and hepatocarcinogenesis, which are both triggered by HBV infection, is outlined. Understanding the fundamental and complex liver regeneration process is expected to provide significant therapeutic advantages for HBV-associated hepatocellular carcinoma.

Citing Articles

Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics.

Ma X, Huang T, Chen X, Li Q, Liao M, Fu L Signal Transduct Target Ther. 2025; 10(1):63.

PMID: 39920130 PMC: 11806117. DOI: 10.1038/s41392-024-02104-8.

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