The Perinatal Factors That Influence the Excretion of Fecal Calprotectin in Premature-born Children

Overview

Journal Open Med (Wars)

Specialty General Medicine

Date 2022 Jul 27

PMID 35892079

Authors

Jelena R Cekovic

Nikola S Prodanovic

Sara S Mijailovic

Sanja M Knezevic

Biljana P Vuletic

Andjelka K Stojkovic

Dragana M Savic

Tijana V Prodanovic

Marina M Stanojevic

Aleksandra M Simovic

Affiliations

Soon will be listed here.

Abstract

This study aimed to provide additional information on the influence of perinatal factors on fecal (f)-calprotectin values in preterm infants. Calprotectin was determined from the first spontaneous stool (analyzed on the Alegria device by using the enzyme-linked immunosorbent assay [ELISA] method) obtained from neonates at a mean age of 3.41 ± 2.44 days of life. We analyzed 114 subjects who had a body weight of 1847.67 ± 418.6 g and were born at a gestational age of 32.6 ± 2.43 weeks, without intestinal and other congenital anomalies or any diseases other than those related to premature birth. The values of f-calprotectin are in a positive correlation with female subjects, intrauterine growth restriction, significant ductus arteriosus, enteral feeding intolerance, postnatal prolonged use of broad-spectrum antibiotics, and values of bicarbonates (analyzed in a sample of capillary arterial blood). Measurement of f-calprotectin in the first 7 days after birth can help to early detect the intestinal distress or early staging of necrotizing enterocolitis in premature infants.

Citing Articles

Faecal zonulin, calprotectin and the infant microbiome in early life.

Bacorn M, Subramanian P, Levy S, Chen Q, Maxwell G, Hourigan S Clin Transl Med. 2024; 14(5):e1695.

PMID: 38773685 PMC: 11109039. DOI: 10.1002/ctm2.1695.

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