Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2022 Jul 27

PMID 35890272

Authors

Valerio Taggi

Mario Riera Romo

Micheline Piquette-Miller

Henriette E Meyer Zu Schwabedissen

Sibylle Neuhoff

Affiliations

Soon will be listed here.

Abstract

Drug transporters play an important role in the maintenance of chemical balance and homeostasis in different tissues. In addition to their physiological functions, they are crucial for the absorption, distribution, and elimination of many clinically important drugs, thereby impacting therapeutic efficacy and toxicity. Increasing evidence has demonstrated that infectious, metabolic, inflammatory, and neurodegenerative diseases alter the expression and function of drug transporters. However, the current knowledge on transporter regulation in critical protective barriers, such as the brain and placenta, is still limited and requires more research. For instance, while many studies have examined P-glycoprotein, it is evident that research on the regulation of highly expressed transporters in the blood-brain barrier and blood-placental barrier are lacking. The aim of this review is to summarize the currently available literature in order to better understand transporter regulation in these critical barriers.

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