Synthesis of Cobalt Bis(Dicarbollide)-Curcumin Conjugates for Potential Use in Boron Neutron Capture Therapy

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 Jul 27

PMID 35889538

Authors

Lyubov G Dezhenkova

Anna A Druzina

Yulia L Volodina

Nadezhda V Dudarova

Natalia A Nekrasova

Olga B Zhidkova

Mikhail A Grin

Vladimir I Bregadze

Affiliations

Soon will be listed here.

Abstract

A series of novel cobalt bis(dicarbollide)-curcumin conjugates were synthesized. Two conjugates were obtained through the nucleophilic ring-opening reaction of the 1,4-dioxane and tetrahydropyran derivatives of cobalt bis(dicarbollide) with the OH group of curcumin, and using two equiv. of the oxonium derivatives, two other conjugates containing two cobalt bis(dicarbollide) units per molecule were obtained. In contrast to curcumin, the conjugates obtained were found to be non-cytotoxic against both tumor and normal cell lines. The analysis of the intracellular accumulation of the conjugates by flow cytometry showed that all cobalt bis(dicarbollide)-curcumin conjugates entered HCT116 colorectal carcinoma cells in a time-dependent manner. New non-cytotoxic conjugates contain a large amount of boron atoms in the biomolecule and can potentially be used for further biological research into boron neutron capture therapy (BNCT).

Citing Articles

Chemistry of Carbon-Substituted Derivatives of Cobalt Bis(dicarbollide)(1) Ion and Recent Progress in Boron Substitution.

Pazderova L, Tuzun E, Bavol D, Litecka M, Fojt L, Gruner B Molecules. 2023; 28(19).

PMID: 37836814 PMC: 10574808. DOI: 10.3390/molecules28196971.

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