Characterization and Comparison of Ocular Surface Microbiome in Newborns

Overview

Journal Microorganisms

Specialty Microbiology

Date 2022 Jul 27

PMID 35889110

Authors

Francesco Petrillo

Arianna Petrillo

Maddalena Marrapodi

Carlo Capristo

Maria Francesca Gicchino

Paolo Montaldo

Elisabetta Caredda

Michele Reibaldi

Lara M V Boatti

Federica DellAnnunziata

Veronica Folliero

Marilena Galdiero

Affiliations

Soon will be listed here.

Abstract

Methods: A total of 20 conjunctival swabs were collected from newborns at birth and after antibiotic treatment. Samples were subjected to 16S rRNA sequencing via system MiSeq Illumina. The data were processed with the MicrobAT software and statistical analysis were performed using two-way ANOVA.

Results: Antibiotic prophylaxis with gentamicin altered the composition of the microbiota. In detail, a 1.5- and 2.01-fold reduction was recorded for () and (), respectively, whereas an increase in spp. of 6.5 times occurred after antibiotic exposure.

Conclusions: Antibiotic prophylaxis altered the ocular microbiota whose understanding could avoid adverse effects on eye health.

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