Determining the International Spread of B.1.1.523 SARS-CoV-2 Lineage with a Set of Mutations Highly Associated with Reduced Immune Neutralization

Overview

Journal Microorganisms

Specialty Microbiology

Date 2022 Jul 27

PMID 35889075

Authors

Lukas Zemaitis

Gediminas Alzbutas

Dovydas Gecys

Arnoldas Pautienius

Rasa Ugenskiene

Marius Sukys

Vaiva Lesauskaite

Affiliations

Soon will be listed here.

Abstract

Here, we report the emergence of the variant lineage B.1.1.523 that contains a set of mutations including 156_158del, E484K and S494P in the spike protein. E484K and S494P are known to significantly reduce SARS-CoV-2 neutralization by convalescent and vaccinated sera and are considered as mutations of concern. Lineage B.1.1.523 presumably originated in the Russian Federation and spread across European countries with the peak of transmission in April-May 2021. The B.1.1.523 lineage has now been reported from 31 countries. In this article, we analyze the possible origin of this mutation subset and its immune response using in silico methods.

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