Intratumoral Budding in Pretreatment Biopsies, Among Tumor Microenvironmental Components, Can Predict Prognosis and Neoadjuvant Therapy Response in Colorectal Adenocarcinoma

Overview

Journal Medicina (Kaunas)

Publisher MDPI

Specialty General Medicine

Date 2022 Jul 27

PMID 35888645

Authors

Kwangil Yim

Won Mo Jang

Uiju Cho

DER Sheng Sun

Yosep Chong

Kyung Jin Seo

Affiliations

Soon will be listed here.

Abstract

The prediction of the prognosis and effect of neoadjuvant therapy is vital for patients with advanced or unresectable colorectal carcinoma (CRC). : We investigated several tumor microenvironment factors, such as intratumoral budding (ITB), desmoplastic reaction (DR), and Klintrup-Mäkinen (KM) inflammation grade, and the tumor-stroma ratio (TSR) in pretreatment biopsy samples (PBSs) collected from patients with advanced or unresectable CRC. A total of 85 patients with 74 rectal carcinomas and 11 colon cancers treated at our hospital were enrolled; 66 patients had curative surgery and 19 patients received palliative treatment. High-grade ITB was associated with recurrence ( = 0.002), death ( = 0.034), and cancer-specific death ( = 0.034). Immature DR was associated with a higher grade of clinical tumor-node-metastasis stage (cTNM) ( = 0.045), cN category ( = 0.045), and cM category ( = 0.046). The KM grade and TSR were not related to any clinicopathological factors. High-grade ITB had a significant relationship with tumor regression in patients who received curative surgery ( = 0.049). High-grade ITB in PBSs is a potential unfavorable prognostic factor for patients with advanced CRC. Immature DR, TSR, and KM grade could not predict prognosis or therapy response in PBSs.

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