UFMylation System: An Emerging Player in Tumorigenesis

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2022 Jul 27

PMID 35884562

Authors

Yu Jing

Ziming Mao

Fengling Chen

Affiliations

Soon will be listed here.

Abstract

Ubiquitin-fold modifier 1 (UFM1), a newly identified ubiquitin-like molecule (UBLs), is evolutionarily expressed in multiple species except yeast. Similarly to ubiquitin, UFM1 is covalently attached to its substrates through a well-orchestrated three-step enzymatic reaction involving E1, the UFM1-activating enzyme (ubiquitin-like modifier-activating enzyme 5, UBA5); E2, the UFM1-conjugating enzyme 1 (UFC1); and E3, the UFM1-specific ligase 1 (UFL1). To date, numerous studies have shown that UFM1 modification is implicated in various cellular processes, including endoplasmic reticulum (ER) stress, DNA damage response and erythroid development. An abnormal UFM1 cascade is closely related to a variety of diseases, especially tumors. Herein, we summarize the process and functions of UFM1 modification, illustrating the relationship and mechanisms between aberrant UFMylation and diversified tumors, aiming to provide novel diagnostic biomarkers or therapeutic targets for cancer treatments.

Citing Articles

Systematic Analysis of UFMylation Family Genes in Tissues of Mice with Metabolic Dysfunction-Associated Steatotic Liver Disease.

Jiang M, Zhang C, Zhang Z, Duan Y, Qi S, Zeng Q Genes (Basel). 2025; 16(1.

PMID: 39858578 PMC: 11765366. DOI: 10.3390/genes16010031.

The UFMylation pathway is impaired in Alzheimer's disease.

Yan T, Heckman M, Craver E, Liu C, Rawlinson B, Wang X Mol Neurodegener. 2024; 19(1):97.

PMID: 39696466 PMC: 11656649. DOI: 10.1186/s13024-024-00784-y.

Loss of LRP1 Promotes Hepatocellular Carcinoma Progression via UFL1-Mediated Activation of NF-κB Signaling.

Guo X, Yang F, Liu T, Chen A, Liu D, Pu J Adv Sci (Weinh). 2024; 11(45):e2401672.

PMID: 39405202 PMC: 11615765. DOI: 10.1002/advs.202401672.

Role of UFMylation in tumorigenesis and cancer immunotherapy.

Ding L, Jiang X, Li T, Wang S Front Immunol. 2024; 15:1454823.

PMID: 39247188 PMC: 11377280. DOI: 10.3389/fimmu.2024.1454823.

The UFMylation pathway is impaired in Alzheimer's disease.

Yan T, Heckman M, Craver E, Liu C, Rawlinson B, Wang X bioRxiv. 2024; .

PMID: 38903110 PMC: 11188091. DOI: 10.1101/2024.05.24.595755.

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