Role of Daptomycin in Cutaneous Wound Healing: A Narrative Review

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2022 Jul 27

PMID 35884198

Authors

Giulio Rizzetto

Elisa Molinelli

Giulia Radi

Federico Diotallevi

Oscar Cirioni

Lucia Brescini

Andrea Giacometti

Annamaria Offidani

Oriana Simonetti

Affiliations

Soon will be listed here.

Abstract

Daptomycin is active against Gram-positive bacteria, including methicillin-resistant (MRSA) and the on-label indications for its use include complicated skin and skin structure infections (cSSSI). We performed a narrative review of the literature with the aim to evaluate the role of daptomycin in the skin wound healing process, proposing our point of view on the possible association with other molecules that could improve the skin healing process. Daptomycin may improve wound healing in MRSA-infected burns, surgical wounds, and diabetic feet, but further studies in humans with histological examination are needed. In the future, the combination of daptomycin with other molecules with synergistic action, such as vitamin E and derivates, IB-367, RNA III-inhibiting peptide (RIP), and palladium nanoflowers, may help to improve wound healing and overcome forms of antibiotic resistance.

Citing Articles

The sources of antimicrobial peptides against Gram-positives and Gramnegatives: our research experience.

Rizzetto G, Gambini D, Maurizi A, Molinelli E, De Simoni E, Pallotta F Infez Med. 2023; 31(3):306-322.

PMID: 37701381 PMC: 10495054. DOI: 10.53854/liim-3103-5.

Our Experience over 20 Years: Antimicrobial Peptides against Gram Positives, Gram Negatives, and Fungi.

Rizzetto G, Gambini D, Maurizi A, Candelora M, Molinelli E, Cirioni O Pharmaceutics. 2023; 15(1).

PMID: 36678669 PMC: 9862542. DOI: 10.3390/pharmaceutics15010040.

Update on the Management of Surgical Site Infections.

Pinchera B, Buonomo A, Schiano Moriello N, Scotto R, Villari R, Gentile I Antibiotics (Basel). 2022; 11(11).

PMID: 36421250 PMC: 9686970. DOI: 10.3390/antibiotics11111608.

MRSA and Skin Infections in Psoriatic Patients: Therapeutic Options and New Perspectives.

Rizzetto G, Molinelli E, Radi G, Cirioni O, Brescini L, Giacometti A Antibiotics (Basel). 2022; 11(11).

PMID: 36358159 PMC: 9686594. DOI: 10.3390/antibiotics11111504.

References

Pierpaoli E, Cirioni O, Barucca A, Orlando F, Silvestri C, Giacometti A . Vitamin E supplementation in old mice induces antimicrobial activity and improves the efficacy of daptomycin in an animal model of wounds infected with methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother. 2011; 66(9):2184-5. DOI: 10.1093/jac/dkr254. View

Silvestri C, Cirioni O, Arzeni D, Ghiselli R, Simonetti O, Orlando F . In vitro activity and in vivo efficacy of tigecycline alone and in combination with daptomycin and rifampin against Gram-positive cocci isolated from surgical wound infection. Eur J Clin Microbiol Infect Dis. 2011; 31(8):1759-64. DOI: 10.1007/s10096-011-1498-1. View

Liu Y, Min D, Bolton T, Nube V, Twigg S, Yue D . Increased matrix metalloproteinase-9 predicts poor wound healing in diabetic foot ulcers. Diabetes Care. 2008; 32(1):117-9. PMC: 2606842. DOI: 10.2337/dc08-0763. View

Ben-David D, Mermel L, Parenteau S . Methicillin-resistant Staphylococcus aureus transmission: the possible importance of unrecognized health care worker carriage. Am J Infect Control. 2008; 36(2):93-7. DOI: 10.1016/j.ajic.2007.05.013. View

Shi H, Lin C, Lin B, Wang Z, Zhang H, Wu F . The anti-scar effects of basic fibroblast growth factor on the wound repair in vitro and in vivo. PLoS One. 2013; 8(4):e59966. PMC: 3615060. DOI: 10.1371/journal.pone.0059966. View

Iwata S, Koyama H, Murata Y . Efficacy and safety of daptomycin in Japanese pediatric participants with complicated skin and soft tissue infections or bacteremia caused by gram-positive cocci. J Infect Chemother. 2021; 28(3):406-412. DOI: 10.1016/j.jiac.2021.11.019. View

Provinciali M, Cirioni O, Orlando F, Pierpaoli E, Barucca A, Silvestri C . Vitamin E improves the in vivo efficacy of tigecycline and daptomycin in an animal model of wounds infected with meticillin-resistant Staphylococcus aureus. J Med Microbiol. 2011; 60(Pt 12):1806-1812. DOI: 10.1099/jmm.0.032516-0. View

Wearn C, Hardwicke J, Moiemen N . Burns in the elderly: Mortality is still a relevant outcome. Burns. 2015; 41(7):1617-8. DOI: 10.1016/j.burns.2015.08.029. View

Barro C, Romanet J, Fdili A, Guillot M, Morel F . Gelatinase concentration in tears of corneal-grafted patients. Curr Eye Res. 1998; 17(2):174-82. DOI: 10.1076/ceyr.17.2.174.5602. View

10.

Abbasi-Montazeri E, Khosravi A, Feizabadi M, Goodarzi H, Khoramrooz S, Mirzaii M . The prevalence of methicillin resistant Staphylococcus aureus (MRSA) isolates with high-level mupirocin resistance from patients and personnel in a burn center. Burns. 2013; 39(4):650-4. DOI: 10.1016/j.burns.2013.02.005. View

11.

OBrien D, Gould I . Does vancomycin have a future in the treatment of skin infections?. Curr Opin Infect Dis. 2014; 27(2):146-54. DOI: 10.1097/QCO.0000000000000048. View

12.

Karas J, Carter G, Howden B, Turner A, Paulin O, Swarbrick J . Structure-Activity Relationships of Daptomycin Lipopeptides. J Med Chem. 2020; 63(22):13266-13290. DOI: 10.1021/acs.jmedchem.0c00780. View

13.

Simonetti O, Cirioni O, Ghiselli R, Goteri G, Scalise A, Orlando F . RNAIII-inhibiting peptide enhances healing of wounds infected with methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2008; 52(6):2205-11. PMC: 2415788. DOI: 10.1128/AAC.01340-07. View

14.

Ambrosch A, Halevy D, Fwity B, Brin T, Lobmann R . Effect of daptomycin on local interleukin-6, matrix metalloproteinase-9, and metallopeptidase inhibitor 1 in patients with MRSA-infected diabetic foot. Int J Low Extrem Wounds. 2013; 12(2):100-5. DOI: 10.1177/1534734613490506. View

15.

Sulaiman J, Lam H . Novel Daptomycin Tolerance and Resistance Mutations in Methicillin-Resistant Staphylococcus aureus from Adaptive Laboratory Evolution. mSphere. 2021; 6(5):e0069221. PMC: 8550074. DOI: 10.1128/mSphere.00692-21. View

16.

Seaton R . Daptomycin: rationale and role in the management of skin and soft tissue infections. J Antimicrob Chemother. 2008; 62 Suppl 3:iii15-23. DOI: 10.1093/jac/dkn368. View

17.

Simonetti O, Cirioni O, Ghiselli R, Orlando F, Silvestri C, Mazzocato S . In vitro activity and in vivo animal model efficacy of IB-367 alone and in combination with imipenem and colistin against Gram-negative bacteria. Peptides. 2014; 55:17-22. DOI: 10.1016/j.peptides.2014.01.029. View

18.

Dukic V, Lauderdale D, Wilder J, Daum R, David M . Epidemics of community-associated methicillin-resistant Staphylococcus aureus in the United States: a meta-analysis. PLoS One. 2013; 8(1):e52722. PMC: 3534721. DOI: 10.1371/journal.pone.0052722. View

19.

Atshan S, Hamat R, Coolen M, Dykes G, Sekawi Z, Mullins B . The Role of Subinhibitory Concentrations of Daptomycin and Tigecycline in Modulating Virulence in . Antibiotics (Basel). 2021; 10(1). PMC: 7823975. DOI: 10.3390/antibiotics10010039. View

20.

Iwamoto M, Mu Y, Lynfield R, Bulens S, Nadle J, Aragon D . Trends in invasive methicillin-resistant Staphylococcus aureus infections. Pediatrics. 2013; 132(4):e817-24. DOI: 10.1542/peds.2013-1112. View