Durable Responses to Chemotherapy in Patients with Metastatic Soft-Tissue Sarcoma

Introduction: Patients with metastatic soft-tissue sarcoma generally have a poor prognosis. Although chemotherapy is associated with improved overall survival in these patients, long-term benefit is rare.

Case Report: We report on 2 patients with metastatic soft-tissue sarcoma who achieved a complete response to chemotherapy, without any local therapy, and had no signs of disease progression more than a decade after discontinuing treatment.

Conclusion: These observations highlight the potential benefit of chemotherapy in a disease that is often considered to be poorly responsive to this treatment. These observations support further efforts to identify factors to guide patient selection and treatment optimization.