Ischemic Heart Disease in Chronic Hepatitis B: A Danish Nationwide Cohort Study

Overview

Journal Clin Epidemiol

Publisher Dove Medical Press

Specialty Public Health

Date 2022 Jul 26

PMID 35879942

Authors

Frederik Faergemann Lau

Signe Bollerup

Frederik Engsig

Henrik Krarup

Lone Hagens Mygind

Jesper Bach Hansen

Lone Galmstrup Madsen

Peter Thielsen

Ulla Balslev

Lars Norregaard Nielsen

Toke S Barfod

Mette Rye Clausen

Lise Hobolth

Alex Lund Laursen

Britta Tarp

Birgit T Roege

Jan Gerstoft

Peer Brehm Christensen

Nina Weis

Affiliations

Soon will be listed here.

Abstract

Objective: Data on the risk of ischemic heart disease (IHD) in patients with chronic hepatitis B virus (CHB) are conflicting. Our objective was to address the rate of IHD in patients with CHB compared with individuals without CHB (control-persons) from the general population.

Study Design And Setting: We conducted a cohort study of prospectively obtained data from Danish nationwide registries. We produced cumulative incidence curves and calculated the unadjusted incidence rate ratio (IRR) of IHD in persons with and without CHB. The adjusted association between having CHB and developing IHD was examined using a cause-specific Cox regression model.

Results: In total, 6472 persons with CHB and 62,251 age- and sex-matched individuals from the general population were followed for 48,840 and 567,456 person-years, respectively, during which 103 (1,59%) with CHB and 1058 (1,70%) control-persons developed IHD. The crude IRR was 1.13 (95% CI: 0.91-1.39). CHB did not have a statistically significant effect on the rate of IHD after adjusting for several confounding factors (adjusted hazard ratio: 0.96, 95% CI: 0.76-1.21).

Conclusion: In this nationwide cohort study, we did not find any difference between rate of IHD in persons with CHB in comparison with the general population.

References

Si J, Yu C, Guo Y, Bian Z, Meng R, Yang L . Chronic hepatitis B virus infection and total and cause-specific mortality: a prospective cohort study of 0.5 million people. BMJ Open. 2019; 9(4):e027696. PMC: 6500223. DOI: 10.1136/bmjopen-2018-027696. View

Joensen A, Jensen M, Overvad K, Dethlefsen C, Schmidt E, Rasmussen L . Predictive values of acute coronary syndrome discharge diagnoses differed in the Danish National Patient Registry. J Clin Epidemiol. 2008; 62(2):188-94. DOI: 10.1016/j.jclinepi.2008.03.005. View

Amin J, Dore G, OConnell D, Bartlett M, Tracey E, Kaldor J . Cancer incidence in people with hepatitis B or C infection: a large community-based linkage study. J Hepatol. 2006; 45(2):197-203. DOI: 10.1016/j.jhep.2006.02.014. View

Marchesini G, Ronchi M, Forlani G, Bugianesi E, Bianchi G, Fabbri A . Cardiovascular disease in cirrhosis--a point-prevalence study in relation to glucose tolerance. Am J Gastroenterol. 1999; 94(3):655-62. DOI: 10.1111/j.1572-0241.1999.00931.x. View

Seto W, Lo Y, Pawlotsky J, Yuen M . Chronic hepatitis B virus infection. Lancet. 2018; 392(10161):2313-2324. DOI: 10.1016/S0140-6736(18)31865-8. View

Quan H, Li B, Couris C, Fushimi K, Graham P, Hider P . Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol. 2011; 173(6):676-82. DOI: 10.1093/aje/kwq433. View

Andersen E, Omland L, Jepsen P, Krarup H, Christensen P, Obel N . Risk of all-type cancer, hepatocellular carcinoma, non-Hodgkin lymphoma and pancreatic cancer in patients infected with hepatitis B virus. J Viral Hepat. 2015; 22(10):828-34. DOI: 10.1111/jvh.12391. View

Tong D, Wang X, Xu C, Yang Y, Xiong S . Hepatitis B virus infection and coronary atherosclerosis: results from a population with relatively high prevalence of hepatitis B virus. World J Gastroenterol. 2005; 11(9):1292-6. PMC: 4250675. DOI: 10.3748/wjg.v11.i9.1292. View

Omland L, Jepsen P, Skinhoj P, Jorgensen H, Munster A, Bangsborg J . The impact of HIV-1 co-infection on long-term mortality in patients with hepatitis C: a population-based cohort study. HIV Med. 2008; 10(2):65-71. DOI: 10.1111/j.1468-1293.2008.00652.x. View

10.

Lynge E, Sandegaard J, Rebolj M . The Danish National Patient Register. Scand J Public Health. 2011; 39(7 Suppl):30-3. DOI: 10.1177/1403494811401482. View

11.

Hansen N, Hay G, Cowan S, Jepsen P, Bygum Krarup H, Obel N . Hepatitis B prevalence in Denmark - an estimate based on nationwide registers and a national screening programme, as on 31 December 2007. Euro Surveill. 2013; 18(47). DOI: 10.2807/1560-7917.es2013.18.47.20637. View

12.

Lee K, Stelzle D, Bing R, Anwar M, Strachan F, Bashir S . Global burden of atherosclerotic cardiovascular disease in people with hepatitis C virus infection: a systematic review, meta-analysis, and modelling study. Lancet Gastroenterol Hepatol. 2019; 4(10):794-804. PMC: 6734111. DOI: 10.1016/S2468-1253(19)30227-4. View

13.

Momiyama Y, Ohmori R, Kato R, Taniguchi H, Nakamura H, Ohsuzu F . Lack of any association between persistent hepatitis B or C virus infection and coronary artery disease. Atherosclerosis. 2005; 181(1):211-3. DOI: 10.1016/j.atherosclerosis.2005.02.027. View

14.

Ishizaka N, Ishizaka Y, Takahashi E, Hashimoto H, Ohno M, Nagai R . Increased prevalence of carotid atherosclerosis in hepatitis B virus carriers. Circulation. 2002; 105(9):1028-30. DOI: 10.1161/hc0902.105718. View

15.

Beasley R . Hepatitis B virus. The major etiology of hepatocellular carcinoma. Cancer. 1988; 61(10):1942-56. DOI: 10.1002/1097-0142(19880515)61:10<1942::aid-cncr2820611003>3.0.co;2-j. View

16.

Joo E, Chang Y, Yeom J, Ryu S . Hepatitis B virus infection and decreased risk of nonalcoholic fatty liver disease: A cohort study. Hepatology. 2016; 65(3):828-835. DOI: 10.1002/hep.28917. View

17.

Katoonizadeh A, Ghoroghi S, Sharafkhah M, Khoshnia M, Mirzaei S, Shayanrad A . Chronic hepatitis B infection is not associated with increased risk of vascular mortality while having an association with metabolic syndrome. J Med Virol. 2016; 88(7):1230-7. DOI: 10.1002/jmv.24466. View

18.

Hao S, Wang Y, Gao G, Li Z . Hepatitis B Virus Upregulates the Expression of C-reactive Protein Both and . Ann Clin Lab Sci. 2017; 47(4):432-435. View

19.

Tang L, Covert E, Wilson E, Kottilil S . Chronic Hepatitis B Infection: A Review. JAMA. 2018; 319(17):1802-1813. DOI: 10.1001/jama.2018.3795. View

20.

Sung J, Song Y, Choi Y, Ebrahim S, Davey Smith G . Hepatitis B virus seropositivity and the risk of stroke and myocardial infarction. Stroke. 2007; 38(5):1436-41. DOI: 10.1161/STROKEAHA.106.466268. View