Selective Cell Size MRI Differentiates Brain Tumors from Radiation Necrosis

Overview

Journal Cancer Res

Specialty Oncology

Date 2022 Jul 25

PMID 35877201

Authors

Sean P Devan

Xiaoyu Jiang

Guozhen Luo

Jingping Xie

James D Quirk

John A Engelbach

Hannah Harmsen

Eliot T McKinley

Jing Cui

Zhongliang Zu

Albert Attia

Joel R Garbow

John C Gore

Colin D McKnight

Austin N Kirschner

Junzhong Xu

Affiliations

Soon will be listed here.

Abstract

Significance: This work introduces and provides preclinical validation of a new diffusion MRI method that exploits intrinsic differences in cell sizes to distinguish brain tumors and radiotherapy necrosis.

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References

Welker K, Boxerman J, Kalnin A, Kaufmann T, Shiroishi M, Wintermark M . ASFNR recommendations for clinical performance of MR dynamic susceptibility contrast perfusion imaging of the brain. AJNR Am J Neuroradiol. 2015; 36(6):E41-51. PMC: 5074767. DOI: 10.3174/ajnr.A4341. View

Valk P, Dillon W . Radiation injury of the brain. AJNR Am J Neuroradiol. 1991; 12(1):45-62. PMC: 8367566. View

Barnholtz-Sloan J, Sloan A, Davis F, Vigneau F, Lai P, Sawaya R . Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. J Clin Oncol. 2004; 22(14):2865-72. DOI: 10.1200/JCO.2004.12.149. View

Wu D, Jiang K, Li H, Zhang Z, Ba R, Zhang Y . Time-Dependent Diffusion MRI for Quantitative Microstructural Mapping of Prostate Cancer. Radiology. 2022; 303(3):578-587. DOI: 10.1148/radiol.211180. View

Jiang X, Xu J, Gore J . Mapping hepatocyte size in vivo using temporal diffusion spectroscopy MRI. Magn Reson Med. 2020; 84(5):2671-2683. PMC: 7402009. DOI: 10.1002/mrm.28299. View

Chang E, Wefel J, Hess K, Allen P, Lang F, Kornguth D . Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol. 2009; 10(11):1037-44. DOI: 10.1016/S1470-2045(09)70263-3. View

Zhou J, Tryggestad E, Wen Z, Lal B, Zhou T, Grossman R . Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nat Med. 2010; 17(1):130-4. PMC: 3058561. DOI: 10.1038/nm.2268. View

Ruben J, Dally M, Bailey M, Smith R, McLean C, Fedele P . Cerebral radiation necrosis: incidence, outcomes, and risk factors with emphasis on radiation parameters and chemotherapy. Int J Radiat Oncol Biol Phys. 2006; 65(2):499-508. DOI: 10.1016/j.ijrobp.2005.12.002. View

Lagerwaard F, Levendag P, Nowak P, Eijkenboom W, Hanssens P, Schmitz P . Identification of prognostic factors in patients with brain metastases: a review of 1292 patients. Int J Radiat Oncol Biol Phys. 1999; 43(4):795-803. DOI: 10.1016/s0360-3016(98)00442-8. View

10.

Kwee R, Kwee T . Dynamic susceptibility MR perfusion in diagnosing recurrent brain metastases after radiotherapy: A systematic review and meta-analysis. J Magn Reson Imaging. 2019; 51(2):524-534. PMC: 7004193. DOI: 10.1002/jmri.26812. View

11.

Xu J, Does M, Gore J . Sensitivity of MR diffusion measurements to variations in intracellular structure: effects of nuclear size. Magn Reson Med. 2009; 61(4):828-33. PMC: 2749035. DOI: 10.1002/mrm.21793. View

12.

Pope W . Brain metastases: neuroimaging. Handb Clin Neurol. 2018; 149:89-112. PMC: 6118134. DOI: 10.1016/B978-0-12-811161-1.00007-4. View

13.

Li H, Deng L, Bai H, Sun J, Cao Y, Tao Y . Diagnostic Accuracy of Amino Acid and FDG-PET in Differentiating Brain Metastasis Recurrence from Radionecrosis after Radiotherapy: A Systematic Review and Meta-Analysis. AJNR Am J Neuroradiol. 2017; 39(2):280-288. PMC: 7410573. DOI: 10.3174/ajnr.A5472. View

14.

Mitsuya K, Nakasu Y, Horiguchi S, Harada H, Nishimura T, Bando E . Perfusion weighted magnetic resonance imaging to distinguish the recurrence of metastatic brain tumors from radiation necrosis after stereotactic radiosurgery. J Neurooncol. 2010; 99(1):81-8. DOI: 10.1007/s11060-009-0106-z. View

15.

Owonikoko T, Arbiser J, Zelnak A, Shu H, Shim H, Robin A . Current approaches to the treatment of metastatic brain tumours. Nat Rev Clin Oncol. 2014; 11(4):203-22. PMC: 4041037. DOI: 10.1038/nrclinonc.2014.25. View

16.

Xu J, Li Y, Lian J, Dou S, Yan F, Wu H . Distinction between postoperative recurrent glioma and radiation injury using MR diffusion tensor imaging. Neuroradiology. 2010; 52(12):1193-9. DOI: 10.1007/s00234-010-0731-4. View

17.

Clark C, Hedehus M, Moseley M . Diffusion time dependence of the apparent diffusion tensor in healthy human brain and white matter disease. Magn Reson Med. 2001; 45(6):1126-9. DOI: 10.1002/mrm.1149. View

18.

Xu J, Does M, Gore J . Numerical study of water diffusion in biological tissues using an improved finite difference method. Phys Med Biol. 2007; 52(7):N111-26. PMC: 2634837. DOI: 10.1088/0031-9155/52/7/N01. View

19.

Chiang G, Kovanlikaya I, Choi C, Ramakrishna R, Magge R, Shungu D . Magnetic Resonance Spectroscopy, Positron Emission Tomography and Radiogenomics-Relevance to Glioma. Front Neurol. 2018; 9:33. PMC: 5807339. DOI: 10.3389/fneur.2018.00033. View

20.

Veraart J, Novikov D, Christiaens D, Ades-Aron B, Sijbers J, Fieremans E . Denoising of diffusion MRI using random matrix theory. Neuroimage. 2016; 142:394-406. PMC: 5159209. DOI: 10.1016/j.neuroimage.2016.08.016. View