Weighing Potential Benefits and Harms of Mycoplasma Genitalium Testing and Treatment Approaches

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2022 Jul 25

PMID 35876565

Authors

Lisa E Manhart

William M Geisler

Catriona S Bradshaw

Jorgen S Jensen

David H Martin

Affiliations

Soon will be listed here.

Citing Articles

Features Associated With Mycoplasma genitalium Infection.

Sheele J, Bragg K Cureus. 2024; 16(10):e72728.

PMID: 39618602 PMC: 11606620. DOI: 10.7759/cureus.72728.

Prevalence of and macrolide resistance in rectal and urine samples among men who have sex with men in Sweden.

Bjartling C, Kertes R, Kristiansen S, Johnsson A, Forslund O Sex Transm Infect. 2024; 100(7):430-434.

PMID: 39089883 PMC: 11503078. DOI: 10.1136/sextrans-2023-056044.

Aetiology of vaginal discharge, urethral discharge, and genital ulcer in sub-Saharan Africa: A systematic review and meta-regression.

Michalow J, Walters M, Edun O, Wybrant M, Davies B, Kufa T PLoS Med. 2024; 21(5):e1004385.

PMID: 38768094 PMC: 11104670. DOI: 10.1371/journal.pmed.1004385.

infection among gay, bisexual and other men who have sex with men in Montréal, Canada.

Le A, Labbe A, Fourmigue A, Dvorakova M, Cox J, Fortin C Can Commun Dis Rep. 2024; 49(11-12):477-486.

PMID: 38504874 PMC: 10946590. DOI: 10.14745/ccdr.v49i1112a03.

Estimation of antimicrobial resistance of Belgium, 2022.

De Baetselier I, Smet H, Kehoe K, Loosen I, Reynders M, Mansoor I Euro Surveill. 2024; 29(7).

PMID: 38362626 PMC: 10986661. DOI: 10.2807/1560-7917.ES.2024.29.7.2300318.

References

Dombrowski J, Wierzbicki M, Newman L, Powell J, Miller A, Dithmer D . Doxycycline Versus Azithromycin for the Treatment of Rectal Chlamydia in Men Who Have Sex With Men: A Randomized Controlled Trial. Clin Infect Dis. 2021; 73(5):824-831. PMC: 8571563. DOI: 10.1093/cid/ciab153. View

Lau A, Kong F, Fairley C, Templeton D, Amin J, Phillips S . Azithromycin or Doxycycline for Asymptomatic Rectal . N Engl J Med. 2021; 384(25):2418-2427. DOI: 10.1056/NEJMoa2031631. View

Wetmore C, Manhart L, Lowens M, Golden M, Whittington W, Xet-Mull A . Demographic, behavioral, and clinical characteristics of men with nongonococcal urethritis differ by etiology: a case-comparison study. Sex Transm Dis. 2011; 38(3):180-6. PMC: 4024216. DOI: 10.1097/OLQ.0b013e3182040de9. View

Lis R, Rowhani-Rahbar A, Manhart L . Mycoplasma genitalium infection and female reproductive tract disease: a meta-analysis. Clin Infect Dis. 2015; 61(3):418-26. DOI: 10.1093/cid/civ312. View

Li Y, Le W, Li S, Cao Y, Su X . Meta-analysis of the efficacy of moxifloxacin in treating Mycoplasma genitalium infection. Int J STD AIDS. 2017; 28(11):1106-1114. DOI: 10.1177/0956462416688562. View

Kjaergaard N, Kristensen B, Hansen E, Farholt S, Schonheyder H, Uldbjerg N . Microbiology of semen specimens from males attending a fertility clinic. APMIS. 1997; 105(7):566-70. DOI: 10.1111/j.1699-0463.1997.tb05054.x. View

Read T, Murray G, Danielewski J, Fairley C, Doyle M, Worthington K . Symptoms, Sites, and Significance of Mycoplasma genitalium in Men Who Have Sex with Men. Emerg Infect Dis. 2019; 25(4):719-727. PMC: 6433010. DOI: 10.3201/eid2504.181258. View

Lusk M, Garden F, Rawlinson W, Naing Z, Cumming R, Konecny P . Cervicitis aetiology and case definition: a study in Australian women attending sexually transmitted infection clinics. Sex Transm Infect. 2015; 92(3):175-81. DOI: 10.1136/sextrans-2015-052332. View

Contini C, Rotondo J, Magagnoli F, Maritati M, Seraceni S, Graziano A . Investigation on silent bacterial infections in specimens from pregnant women affected by spontaneous miscarriage. J Cell Physiol. 2018; 234(1):100-107. DOI: 10.1002/jcp.26952. View

10.

Li Y, Su X, Le W, Li S, Yang Z, Chaisson C . Mycoplasma genitalium in Symptomatic Male Urethritis: Macrolide Use Is Associated With Increased Resistance. Clin Infect Dis. 2019; 70(5):805-810. PMC: 7390511. DOI: 10.1093/cid/ciz294. View

11.

Wang R, Trent M, Bream J, Nilles T, Gaydos C, Carson K . Mycoplasma genitalium Infection Is Not Associated With Genital Tract Inflammation Among Adolescent and Young Adult Women in Baltimore, Maryland. Sex Transm Dis. 2021; 49(2):139-144. PMC: 8755577. DOI: 10.1097/OLQ.0000000000001524. View

12.

Alfarraj D, Somily A . Isolation of Mycoplasma genitalium from endocervical swabs of infertile women. Saudi Med J. 2017; 38(5):549-552. PMC: 5447219. DOI: 10.15537/smj.2017.5.18820. View

13.

Baczynska A, Funch P, Fedder J, Knudsen H, Birkelund S, Christiansen G . Morphology of human Fallopian tubes after infection with Mycoplasma genitalium and Mycoplasma hominis--in vitro organ culture study. Hum Reprod. 2006; 22(4):968-79. DOI: 10.1093/humrep/del455. View

14.

Ajani T, Oluwasola T, Ajani M, Bakare R . The prevalence of, and risk factors for, mycoplasma genitalium infection among infertile women in Ibadan: A cross-sectional study. Int J Reprod Biomed. 2018; 15(10):613-618. PMC: 5767641. View

15.

Taylor B, Zheng X, OConnell C, Wiesenfeld H, Hillier S, Darville T . Risk factors for endometritis and incident infection: a secondary data analysis of the T cell Response Against Chlamydia (TRAC) Study. Sex Transm Infect. 2018; 94(6):414-420. PMC: 6295147. DOI: 10.1136/sextrans-2017-053376. View

16.

Durukan D, Doyle M, Murray G, Bodiyabadu K, Vodstrcil L, Chow E . Doxycycline and Sitafloxacin Combination Therapy for Treating Highly Resistant Mycoplasma genitalium. Emerg Infect Dis. 2020; 26(8):1870-1874. PMC: 7392426. DOI: 10.3201/eid2608.191806. View

17.

Wiesenfeld H, Meyn L, Darville T, Macio I, Hillier S . A Randomized Controlled Trial of Ceftriaxone and Doxycycline, With or Without Metronidazole, for the Treatment of Acute Pelvic Inflammatory Disease. Clin Infect Dis. 2020; 72(7):1181-1189. PMC: 8028096. DOI: 10.1093/cid/ciaa101. View

18.

Jensen J, Norgaard C, Scangarella-Oman N, Unemo M . activity of the first-in-class triazaacenaphthylene gepotidacin alone and in combination with doxycycline against drug-resistant and -susceptible . Emerg Microbes Infect. 2020; 9(1):1388-1392. PMC: 7473033. DOI: 10.1080/22221751.2020.1775498. View

19.

Scholes D, Stergachis A, Heidrich F, Andrilla H, Holmes K, Stamm W . Prevention of pelvic inflammatory disease by screening for cervical chlamydial infection. N Engl J Med. 1996; 334(21):1362-6. DOI: 10.1056/NEJM199605233342103. View

20.

Chow E, Lee D, Bond S, Fairley C, Maddaford K, Wigan R . Nonclassical Pathogens as Causative Agents of Proctitis in Men who Have Sex With Men. Open Forum Infect Dis. 2021; 8(7):ofab137. PMC: 8521645. DOI: 10.1093/ofid/ofab137. View