Roles of Non-Coding RNAs in Primary Biliary Cholangitis

Overview

Journal Front Mol Biosci

Specialty Biology

Date 2022 Jul 25

PMID 35874606

Authors

Yaqin Zhang

Ziying Jiao

Mingwei Chen

Bing Shen

Zongwen Shuai

Affiliations

Soon will be listed here.

Abstract

Primary biliary cholangitis (PBC) is an autoimmune-mediated chronic cholestatic liver disease, fatigue, and skin itching are the most common clinical symptoms. Its main pathological feature is the progressive damage and destruction of bile duct epithelial cells. Non-coding RNA (NcRNA, mainly including microRNA, long non-coding RNA and circular RNA) plays a role in the pathological and biological processes of various diseases, especially autoimmune diseases. Many validated ncRNAs are expected to be biomarkers for the diagnosis or treatment of PBC. This review will elucidate the pathogenesis of PBC and help to identify potential ncRNA biomarkers for PBC.

Citing Articles

Current Perspectives on the Molecular and Clinical Relationships between Primary Biliary Cholangitis and Hepatocellular Carcinoma.

Floreani A, Gabbia D, De Martin S Int J Mol Sci. 2024; 25(4).

PMID: 38396870 PMC: 10888596. DOI: 10.3390/ijms25042194.

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