Artificially Regulated Synthesis of Nanocrystals in Live Cells

Overview

Journal Natl Sci Rev

Date 2022 Jul 25

PMID 35874310

Authors

An-An Liu

En-Ze Sun

Zhi-Gang Wang

Shu-Lin Liu

Dai-Wen Pang

Affiliations

Soon will be listed here.

Abstract

Live cells, as reservoirs of biochemical reactions, can serve as amazing integrated chemical plants where precursor formation, nucleation and growth of nanocrystals, and functional assembly, can be carried out accurately following an artificial program. It is crucial but challenging to deliberately direct intracellular pathways to synthesize desired nanocrystals that cannot be produced naturally in cells, because the relevant reactions exist in different spatiotemporal dimensions and will never encounter each other spontaneously. This article summarizes the progress in the introduction of inorganic functional nanocrystals into live cells via the 'artificially regulated space-time-coupled live-cell synthesis' strategy. We also describe ingenious bio-applications of nanocrystal-cell systems, and quasi-biosynthesis strategies expanded from live-cell synthesis. Artificially regulated live-cell synthesis-which involves the interdisciplinary application of biology, chemistry, nanoscience and medicine-will enable researchers to better exploit the unanticipated potentialities of live cells and open up new directions in synthetic biology.

Citing Articles

synthesis of quantum dots in the nucleus of live cells.

Hu Y, Wang Z, Fu H, Zhou C, Cai W, Shao X Natl Sci Rev. 2024; 11(3):nwae021.

PMID: 38410827 PMC: 10896589. DOI: 10.1093/nsr/nwae021.

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