The Discovery of Penta-peptides Inhibiting the Activity of the Formylglycine-generating Enzyme and Their Potential Antibacterial Effects Against

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 Jul 25

PMID 35873338

Authors

Nicholas Asiimwe

Mohammad Faysal Al Mazid

Yong Taek Jeong

Juyong Lee

Jun-Seok Lee

Affiliations

Soon will be listed here.

Abstract

The formylglycine-generating enzyme is a key regulator that converts sulfatase into an active form. Despite its key role in many diseases, enzyme activity inhibitors have not yet been reported. In this study, we investigated penta-peptide ligands for FGE activity inhibition and discovered two hit peptides. In addition, the lead peptides also showed potential antibacterial effects in a model.

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