Interaction Between Intrinsic Renal Cells and Immune Cells in the Progression of Acute Kidney Injury

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2022 Jul 25

PMID 35872775

Authors

Junhui Deng

Zhifen Wu

Yun He

Lirong Lin

Wei Tan

Jurong Yang

Affiliations

Soon will be listed here.

Abstract

A growing number of studies have confirmed that immune cells play various key roles in the pathophysiology of acute kidney injury (AKI) development. After the resident immune cells and intrinsic renal cells are damaged by ischemia and hypoxia, drugs and toxins, more immune cells will be recruited to infiltrate through the release of chemokines, while the intrinsic cells promote macrophage polarity conversion, and the immune cells will promote various programmed deaths, phenotypic conversion and cycle arrest of the intrinsic cells, ultimately leading to renal impairment and fibrosis. In the complex and dynamic immune microenvironment of AKI, the bidirectional interaction between immune cells and intrinsic renal cells affects the prognosis of the kidney and the progression of fibrosis, and determines the ultimate fate of the kidney.

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