Lighting the Way to Host-directed Immunotherapeutics
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Abstract
Developing broad-spectrum, host-directed antiviral therapeutics can be adapted to combat emerging viruses. In this issue of Cell Chemical Biology, Maarifi and colleagues implement a Nano luciferase reporter-based protein complementation assay to screen for small molecules and identify Gilteritinib, which enhances interferon induction and antagonizes virus replication.
References
1.
Dhillon S
. Gilteritinib: First Global Approval. Drugs. 2019; 79(3):331-339.
DOI: 10.1007/s40265-019-1062-3.
View
2.
Lemke G
. Biology of the TAM receptors. Cold Spring Harb Perspect Biol. 2013; 5(11):a009076.
PMC: 3809585.
DOI: 10.1101/cshperspect.a009076.
View
3.
Sharif M, Sosic D, Rothlin C, Kelly E, Lemke G, Olson E
. Twist mediates suppression of inflammation by type I IFNs and Axl. J Exp Med. 2006; 203(8):1891-901.
PMC: 2118370.
DOI: 10.1084/jem.20051725.
View
4.
McNab F, Mayer-Barber K, Sher A, Wack A, OGarra A
. Type I interferons in infectious disease. Nat Rev Immunol. 2015; 15(2):87-103.
PMC: 7162685.
DOI: 10.1038/nri3787.
View
5.
Maarifi G, Martin M, Zebboudj A, Boulay A, Nouaux P, Fernandez J
. Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses. Cell Chem Biol. 2022; 29(7):1113-1125.e6.
PMC: 9213012.
DOI: 10.1016/j.chembiol.2022.05.009.
View