Flavin Metallaphotoredox Catalysis: Synergistic Synthesis in Water

Overview

Journal ACS Catal

Publisher American Chemical Society

Date 2022 Jul 22

PMID 35865831

Authors

Maheshwerreddy Chilamari

Jacob R Immel

Pei-Hsuan Chen

Bayan M Alghafli

Steven Bloom

Affiliations

Soon will be listed here.

Abstract

Combining a transition metal with a photocatalyst can drive modern synthetic chemistry. For transformations performed in water, this concept has been largely unexplored. We report the successful merger of a biocompatible flavin photocatalyst with a palladium catalyst to build isotopically enriched peptidomimetics, to mediate conjugate addition and functionalization reactions, and to assemble unprotected proteinogenic and nonproteinogenic peptides, in water. We detail the important role of the ligand and the palladium oxidation state for controlling product selectivity when constructing synthetic peptides.

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