Emerging Role of Non-Coding RNAs in Senescence

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2022 Jul 22

PMID 35865636

Authors

Soudeh Ghafouri-Fard

Tayyebeh Khoshbakht

Bashdar Mahmud Hussen

Aria Baniahmad

Wojciech Branicki

Mohammad Taheri

Ahmad Eghbali

Affiliations

Soon will be listed here.

Abstract

Senescence is defined as a gradual weakening of functional features of a living organism. Cellular senescence is a process that is principally aimed to remove undesirable cells by prompting tissue remodeling. This process is also regarded as a defense mechanism induced by cellular damage. In the course of oncogenesis, senescence can limit tumor progression. However, senescence participates in the pathoetiology of several disorders such as fibrotic disorders, vascular disorders, diabetes, renal disorders and sarcopenia. Recent studies have revealed contribution of different classes of non-coding RNAs in the cellular senescence. Long non-coding RNAs, microRNAs and circular RNAs are three classes of these transcripts whose contributions in this process have been more investigated. In the current review, we summarize the available literature on the impact of these transcripts in the cellular senescence.

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