Generation of Gal-enhanced Bifunctional Tumor Vaccine

Overview

Journal Acta Pharm Sin B

Publisher Elsevier

Specialty Pharmacology

Date 2022 Jul 22

PMID 35865091

Authors

Jian He

Yu Huo

Zhikun Zhang

Yiqun Luo

Xiuli Liu

Qiaoying Chen

Pan Wu

Wei Shi

Tao Wu

Chao Tang

Huixue Wang

Lan Li

Xiyu Liu

Yong Huang

Yongxiang Zhao

Lu Gan

Bing Wang

Liping Zhong

Affiliations

Soon will be listed here.

Abstract

Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis and high mortality. In this study, we demonstrated a novel vaccine targeting HCC and tumor neovascular endothelial cells by fusing recombinant MHCC97H cells expressing porcine -1,3-galactose epitopes (Gal) and endorphin extracellular domains (END) with dendritic cells (DCs) from healthy volunteers. END/Gal-MHCC97H/DC fusion cells induced cytotoxic T lymphocytes (CTLs) and secretion of interferon-gamma (IFN-). CTLs targeted cells expressing Gal and END and tumor angiogenesis. The fused cell vaccine can effectively inhibit tumor growth and prolong the survival time of human hepatoma mice, indicating the high clinical potential of this new cell based vaccine.

Citing Articles

A metabolic intervention strategy to break evolutionary adaptability of tumor for reinforced immunotherapy.

Feng Q, Hao Y, Yang S, Yuan X, Chen J, Mei Y Acta Pharm Sin B. 2023; 13(2):775-786.

PMID: 36873182 PMC: 9979089. DOI: 10.1016/j.apsb.2022.10.021.

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