The Role of Hypochlorous Acid in the Management of Eye Infections: a Case Series

Overview

Journal Drugs Context

Specialty Pharmacology

Date 2022 Jul 22

PMID 35865000

Authors

Chiara Bertone

Antonella Mollicone

Stefano Russo

Paola Sasso

Romina Fasciani

Cinzia Riccardi

Mirella Lizzano

Affiliations

Soon will be listed here.

Abstract

Experiences from clinical practice suggest that hypochlorous acid (HOCl) used as adjuvant treatment can shorten the time to clinical resolution of blepharitis, particularly in relation to the ophthalmic complications that often occur with a blepharitis diagnosis. In addition, in clinical practice, HOCl adjuvant treatment also resulted in a viable option for the management of ophthalmic disorders other than blepharitis. This case series presents and discusses real-life experiences with using an HOCl ophthalmic spray to manage eye infections, further characterizing the use of HOCl for ophthalmic applications.

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References

Sakarya S, Gunay N, Karakulak M, Ozturk B, Ertugrul B . Hypochlorous Acid: an ideal wound care agent with powerful microbicidal, antibiofilm, and wound healing potency. Wounds. 2015; 26(12):342-50. View

Romanowski E, Stella N, Yates K, Brothers K, Kowalski R, Shanks R . In Vitro Evaluation of a Hypochlorous Acid Hygiene Solution on Established Biofilms. Eye Contact Lens. 2018; 44 Suppl 2:S187-S191. PMC: 6046278. DOI: 10.1097/ICL.0000000000000456. View

Tran A, Topilow N, Rong A, Persad P, Lee M, Lee J . Comparison of Skin Antiseptic Agents and the Role of 0.01% Hypochlorous Acid. Aesthet Surg J. 2020; 41(10):1170-1175. PMC: 8438591. DOI: 10.1093/asj/sjaa322. View

Armstrong D, Bohn G, Glat P, Kavros S, Kirsner R, Snyder R . Expert Recommendations for the Use of Hypochlorous Solution: Science and Clinical Application. Ostomy Wound Manage. 2017; 61(5):S2-S19. View

Stroman D, Mintun K, Epstein A, Brimer C, Patel C, Branch J . Reduction in bacterial load using hypochlorous acid hygiene solution on ocular skin. Clin Ophthalmol. 2017; 11:707-714. PMC: 5402722. DOI: 10.2147/OPTH.S132851. View

Schwartz S, Flynn Jr H, Das T, Mieler W . Ocular Infection: Endophthalmitis. Dev Ophthalmol. 2015; 55:176-88. PMC: 5548375. DOI: 10.1159/000431195. View

Del Rosso J, Bhatia N . Status Report on Topical Hypochlorous Acid: Clinical Relevance of Specific Formulations, Potential Modes of Action, and Study Outcomes. J Clin Aesthet Dermatol. 2018; 11(11):36-39. PMC: 6303114. View

Sklar B, Gervasio K, Leng S, Ghosh A, Chari A, Wu A . Management and outcomes of proteasome inhibitor associated chalazia and blepharitis: a case series. BMC Ophthalmol. 2019; 19(1):110. PMC: 6518763. DOI: 10.1186/s12886-019-1118-x. View

Li Z, Wang H, Liang M, Li Z, Li Y, Zhou X . Hypochlorous Acid Can Be the Novel Option for the Meibomian Gland Dysfunction Dry Eye through Ultrasonic Atomization. Dis Markers. 2022; 2022:8631038. PMC: 8754612. DOI: 10.1155/2022/8631038. View

10.

Wang L, Bassiri M, Najafi R, Najafi K, Yang J, Khosrovi B . Hypochlorous acid as a potential wound care agent: part I. Stabilized hypochlorous acid: a component of the inorganic armamentarium of innate immunity. J Burns Wounds. 2007; 6:e5. PMC: 1853323. View

11.

Lee C, Tsai H, Shin-Jung Lee S, Chen Y . Orbital apex syndrome: an unusual complication of herpes zoster ophthalmicus. BMC Infect Dis. 2015; 15:33. PMC: 4314774. DOI: 10.1186/s12879-015-0760-z. View

12.

Ishihara M, Murakami K, Fukuda K, Nakamura S, Kuwabara M, Hattori H . Stability of Weakly Acidic Hypochlorous Acid Solution with Microbicidal Activity. Biocontrol Sci. 2017; 22(4):223-227. DOI: 10.4265/bio.22.223. View

13.

Landa-Solis C, Gonzalez-Espinosa D, Guzman-Soriano B, Snyder M, Reyes-Teran G, Torres K . Microcyn: a novel super-oxidized water with neutral pH and disinfectant activity. J Hosp Infect. 2005; 61(4):291-9. DOI: 10.1016/j.jhin.2005.04.021. View

14.

Finger P, Fam A, Tomar A, Garg G, Chin K . COVID-19 prophylaxis in ophthalmology. Indian J Ophthalmol. 2020; 68(10):2062-2063. PMC: 7728000. DOI: 10.4103/ijo.IJO_2459_20. View

15.

Fam A, Finger P, Tomar A, Garg G, Chin K . Hypochlorous acid antiseptic washout improves patient comfort after intravitreal injection: A patient reported outcomes study. Indian J Ophthalmol. 2020; 68(11):2439-2444. PMC: 7774204. DOI: 10.4103/ijo.IJO_2001_20. View

16.

Anagnostopoulos A, Rong A, Miller D, Tran A, Head T, Lee M . 0.01% Hypochlorous Acid as an Alternative Skin Antiseptic: An In Vitro Comparison. Dermatol Surg. 2018; 44(12):1489-1493. DOI: 10.1097/DSS.0000000000001594. View

17.

Onghanseng N, Ng S, Halim M, Nguyen Q . Oral antibiotics for chronic blepharitis. Cochrane Database Syst Rev. 2021; 6:CD013697. PMC: 8189606. DOI: 10.1002/14651858.CD013697.pub2. View

18.

Bakacs T . Healing of Severe Herpes Zoster Ophthalmicus Within a Few Days: An Autobiographical Case Report. Cureus. 2022; 13(12):e20303. PMC: 8742607. DOI: 10.7759/cureus.20303. View

19.

Yang S, Wu B, Cheng Z, Li L, Zhang Y, Zhao H . The Microbiome of Meibomian Gland Secretions from Patients with Internal Hordeolum Treated with Hypochlorous Acid Eyelid Wipes. Dis Markers. 2022; 2022:7550090. PMC: 8894068. DOI: 10.1155/2022/7550090. View