Functional Interplay Between Long Non-coding RNAs and Breast CSCs

Overview

Journal Cancer Cell Int

Publisher Biomed Central

Date 2022 Jul 21

PMID 35864503

Authors

Bashdar Mahmud Hussen

Ramiar Kamal Kheder

Sara Tharwat Abdullah

Hazha Jamal Hidayat

Heshu Sulaiman Rahman

Abbas Salihi

Mohammad Taheri

Soudeh Ghafouri-Fard

Affiliations

Soon will be listed here.

Abstract

Breast cancer (BC) represents aggressive cancer affecting most women's lives globally. Metastasis and recurrence are the two most common factors in a breast cancer patient's poor prognosis. Cancer stem cells (CSCs) are tumor cells that are able to self-renew and differentiate, which is a significant factor in metastasis and recurrence of cancer. Long non-coding RNAs (lncRNAs) describe a group of RNAs that are longer than 200 nucleotides and do not have the ability to code for proteins. Some of these lncRNAs can be mainly produced in various tissues and tumor forms. In the development and spread of malignancies, lncRNAs have a significant role in influencing multiple signaling pathways positively or negatively, making them promise useful diagnostic and prognostic markers in treating the disease and guiding clinical therapy. However, it is not well known how the interaction of lncRNAs with CSCs will affect cancer development and progression.Here, in this review, we attempt to summarize recent findings that focus on lncRNAs affect cancer stem cell self-renewal and differentiation in breast cancer development and progression, as well as the strategies and challenges for overcoming lncRNA's therapeutic resistance.

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