MiR-203 is an Anti-obese MicroRNA by Targeting Apical Sodium-dependent Bile Acid Transporter

Overview

Journal iScience

Publisher Cell Press

Date 2022 Jul 20

PMID 35856025

Authors

Xin Liu

Feiran Cheng

Xue Bai

Tong Zhao

Limin Zhao

Lei Wang

Mingqi Li

Xianxian Wu

Xiaohui Chen

Pingping Tang

Mengxue Wang

Lintong Jiang

Chaoqi Yan

Fenghua Pei

Xu Gao

Ning Ma

Baofeng Yang

Yong Zhang

Affiliations

Soon will be listed here.

Abstract

Obesity is characterized by excessive fat deposition within the body. Bile acids (BA) are important regulators for controlling the absorption of lipid. Here we show that miR-203 exerts weight-loss and lipid-lowering effects by increasing total BA excretion in obese rodents. miR-203 overexpression transgenic mice are resistant to high-fat diet (HFD)-induced obesity and dyslipidemia. Moreover, the knockdown of miR-203 deteriorates metabolic disorders. ASBT plays important role in regulating BA homeostasis and is a direct target of miR-203. In human intestinal epithelial cells, overexpression of miR-203 decreases the cellular uptake of BA by inhibiting ASBT. Furthermore, TCF7L2 is downregulated in obese mice and acts as a transcription factor of miR-203. The ASBT mRNA level was positively correlated with the body mass index (BMI) of population, while the miR-203 level was negatively associated with BMI. Taken together, these data suggest miR-203 could be a new therapeutic BA regulator for obesity and dyslipidemia.

Citing Articles

MiR-203 improves cardiac dysfunction by targeting PARP1-NAD axis in aging murine.

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Yang M, Liu S, Zhang C Healthcare (Basel). 2022; 10(9).

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