Application and Modification of Bone Cement in Vertebroplasty: A Literature Review

Overview

Journal Jt Dis Relat Surg

Date 2022 Jul 19

PMID 35852210

Authors

Qian Wang

Jun-Feng Dong

Xu Fang

Yang Chen

Affiliations

Soon will be listed here.

Abstract

Vertebral compression fractures are more common in the elderly, particularly in postmenopausal women. Most of these people are accompanied by osteoporosis, which can easily lead to spinal deformities and fractures. Once a fracture occurs, the patient would have severe pain response, limited spinal movement, and need to stay in bed for a long time, resulting in a significant decrease in their quality of life. Percutaneous vertebroplasty (PVP) is a minimally invasive spinal surgery that injects bone cement into the diseased vertebrae for therapeutic purposes. It can quickly relieve pain and stabilize the spine. It is widely used in the treatment of vertebral compression fractures and is currently an ideal treatment method. There are many materials of bone cement used in clinical treatment, and each material has unique characteristics. Many scholars would modify the bone cement according to the advantages and disadvantages to make it more suitable for clinical use. In this review, we discuss the clinical application and modification of bone cement.

Citing Articles

A 0.2 T-0.4 T Static Magnetic Field Improves the Bone Quality of Mice Subjected to Hindlimb Unloading and Reloading Through the Dual Regulation of BMSCs via Iron Metabolism.

Wang J, Zhen C, Zhang G, Yang Z, Shang P Int J Mol Sci. 2024; 25(23).

PMID: 39684847 PMC: 11642155. DOI: 10.3390/ijms252313136.

An unexpected cause of intractable dysphagia after 20 years following cervical spine instrumentation using bone cement alone: a case report.

Bohara S, Thapa B, Regmi P, Shilpakar S Ann Med Surg (Lond). 2024; 86(12):7444-7448.

PMID: 39649892 PMC: 11623810. DOI: 10.1097/MS9.0000000000002728.

In Vitro Osteo-Immunological Responses of Bioactive Calcium Phosphate-Containing Urethane Dimethacrylate-Based Composites: A Potential Alternative to Poly(methyl methacrylate) Bone Cement.

Singhatanadgit W, Sungkhaphan P, Thavornyutikarn B, Kitpakornsanti S, Young A, Janvikul W ACS Mater Au. 2024; 4(6):612-627.

PMID: 39554857 PMC: 11565289. DOI: 10.1021/acsmaterialsau.4c00037.

Comparison of the efficacy and safety of unilateral and bilateral approach kyphoplasty in the treatment of osteoporotic vertebral compression fractures: A meta-analysis.

Sun Y, Li X, Ma S, Chong H, Cai T, Li K Jt Dis Relat Surg. 2024; 35(3):491-503.

PMID: 39189557 PMC: 11411882. DOI: 10.52312/jdrs.2024.1701.

A meta-analysis comparing the efficacy of mineralized collagen-polymethylmethacrylate and polymethylmethacrylate bone cements in the treatment of vertebral compression fractures.

Li S, Li X, Bai X, Wang Y, Han P, Li H PLoS One. 2024; 19(3):e0299325.

PMID: 38457423 PMC: 10923492. DOI: 10.1371/journal.pone.0299325.

References

Liu C, Gai W, Pan S, Liu Z . The exothermal behavior in the hydration process of calcium phosphate cement. Biomaterials. 2003; 24(18):2995-3003. DOI: 10.1016/s0142-9612(03)00125-x. View

Grubhofer F, Imam M, Wieser K, Achermann Y, Meyer D, Gerber C . Staged Revision With Antibiotic Spacers for Shoulder Prosthetic Joint Infections Yields High Infection Control. Clin Orthop Relat Res. 2018; 476(1):146-152. PMC: 5919231. DOI: 10.1007/s11999.0000000000000049. View

Wynn-Jones G, Shelton R, Hofmann M . Development of Portland cement for orthopedic applications, establishing injectability and decreasing setting times. J Biomed Mater Res B Appl Biomater. 2012; 100(8):2213-21. DOI: 10.1002/jbm.b.32790. View

Xia Y, Chen H, Zhang F, Wang L, Chen B, Reynolds M . Injectable calcium phosphate scaffold with iron oxide nanoparticles to enhance osteogenesis via dental pulp stem cells. Artif Cells Nanomed Biotechnol. 2018; 46(sup1):423-433. DOI: 10.1080/21691401.2018.1428813. View

Chen C, Lv G, Xu B, Zhang X, Ma X . Posterior short-segment instrumentation and limited segmental decompression supplemented with vertebroplasty with calcium sulphate and intermediate screws for thoracolumbar burst fractures. Eur Spine J. 2014; 23(7):1548-57. DOI: 10.1007/s00586-014-3374-z. View

Motisuke M, Santos V, Bazanini N, Bertran C . Apatite bone cement reinforced with calcium silicate fibers. J Mater Sci Mater Med. 2014; 25(10):2357-63. DOI: 10.1007/s10856-014-5280-7. View

Chang Y, Tai C, Hsu H, Hsieh P, Lee M, Ueng S . Liquid antibiotics in bone cement: an effective way to improve the efficiency of antibiotic release in antibiotic loaded bone cement. Bone Joint Res. 2014; 3(8):246-51. PMC: 4127657. DOI: 10.1302/2046-3758.38.2000305. View

Jun S, Lee E, Jang T, Kim H, Jang J, Koh Y . Bone morphogenic protein-2 (BMP-2) loaded hybrid coating on porous hydroxyapatite scaffolds for bone tissue engineering. J Mater Sci Mater Med. 2013; 24(3):773-82. DOI: 10.1007/s10856-012-4822-0. View

Semaan H, Obri T, Bazerbashi M, Paull D, Liu X, Sarrouj M . Clinical outcome and subsequent sequelae of cement extravasation after percutaneous kyphoplasty and vertebroplasty: a comparative review. Acta Radiol. 2017; 59(7):861-868. DOI: 10.1177/0284185117732599. View

10.

Huan Z, Chang J . Novel tricalcium silicate/monocalcium phosphate monohydrate composite bone cement. J Biomed Mater Res B Appl Biomater. 2007; 82(2):352-9. DOI: 10.1002/jbm.b.30740. View

11.

Kanter B, Vikman A, Bruckner T, Schamel M, Gbureck U, Ignatius A . Bone regeneration capacity of magnesium phosphate cements in a large animal model. Acta Biomater. 2018; 69:352-361. DOI: 10.1016/j.actbio.2018.01.035. View

12.

Hakimi S, Schumacher K, Ring A . Angle-stable polyaxial locked plating with and without polymethylmethacrylate cement augmentation for proximal humeral fractures in elderly. Jt Dis Relat Surg. 2021; 32(3):575-582. PMC: 8650664. DOI: 10.52312/jdrs.2021.360. View

13.

Geibel P, Boyd D, Slabisak V . The use of recombinant human bone morphogenic protein in posterior interbody fusions of the lumbar spine: a clinical series. J Spinal Disord Tech. 2009; 22(5):315-20. DOI: 10.1097/BSD.0b013e31817d8161. View

14.

Palussiere J, Berge J, Gangi A, Cotten A, Pasco A, Bertagnoli R . Clinical results of an open prospective study of a bis-GMA composite in percutaneous vertebral augmentation. Eur Spine J. 2005; 14(10):982-91. DOI: 10.1007/s00586-003-0664-2. View

15.

Yang G, Liu J, Li F, Pan Z, Ni X, Shen Y . Bioactive calcium sulfate/magnesium phosphate cement for bone substitute applications. Mater Sci Eng C Mater Biol Appl. 2014; 35:70-6. DOI: 10.1016/j.msec.2013.10.016. View

16.

Wu C, Wang C, Lu D, Hsu L, Yang K, Lin F . Calcium phosphate cement delivering zoledronate decreases bone turnover rate and restores bone architecture in ovariectomized rats. Biomed Mater. 2012; 7(3):035009. DOI: 10.1088/1748-6041/7/3/035009. View

17.

Bernhardt A, Schamel M, Gbureck U, Gelinsky M . Osteoclastic differentiation and resorption is modulated by bioactive metal ions Co2+, Cu2+ and Cr3+ incorporated into calcium phosphate bone cements. PLoS One. 2017; 12(8):e0182109. PMC: 5538673. DOI: 10.1371/journal.pone.0182109. View

18.

Wynn-Jones G, Shelton R, Hofmann M . Injectable citrate-modified Portland cement for use in vertebroplasty. J Biomed Mater Res B Appl Biomater. 2014; 102(8):1799-808. PMC: 4657479. DOI: 10.1002/jbm.b.33160. View

19.

Wang Q, Sun C, Zhang L, Wang L, Ji Q, Min N . High- versus low-viscosity cement vertebroplasty and kyphoplasty for osteoporotic vertebral compression fracture: a meta-analysis. Eur Spine J. 2022; 31(5):1122-1130. DOI: 10.1007/s00586-022-07150-w. View

20.

Yoshii T, Ueki H, Kato T, Tomizawa S, Okawa A . Severe kyphotic deformity resulting from collapses of cemented and adjacent vertebrae following percutaneous vertebroplasty using calcium phosphate cement. A case report. Skeletal Radiol. 2014; 43(10):1477-80. DOI: 10.1007/s00256-014-1912-8. View